HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells.
HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells.
复制标题
MTB衍生的抗原对人CD8+ T细胞的HLA-E依赖性表现。
DOI：
10.1084/jem.20020609
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发表时间：
2002-12-02
影响因子：
15.3
通讯作者：
Lewinsohn, David M
中科院分区：
文献类型：
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作者：
Heinzel, Amy S;Grotzke, Jeff E;Lines, Rebecca A;Lewinsohn, Deborah A;McNabb, Andria L;Streblow, Daniel N;Braud, Veronique M;Grieser, Heather J;Belisle, John T;Lewinsohn, David M
先前在小鼠和人类中的研究已经表明CD 8 + T细胞在宿主防御Mtb中的重要作用。最近，我们已经描述了既不是HLA-A、B或C也不是1组CD 1限制性的人Mtb特异性CD 8+细胞，并且已经发现这些细胞在潜伏感染个体中包含显性CD 8 + T细胞应答。在这份报告中，三个独立的方法被用来证明这些细胞识别结核分枝杆菌衍生抗原的单态HLA-E分子的背景下的能力。这是HLA-E呈递病原体衍生抗原的能力的首次证明。HLA-E特异性反应的进一步定义可能有助于开发有效的结核病疫苗。
Previous studies in mice and humans have suggested an important role for CD8+ T cells in host defense to Mtb. Recently, we have described human, Mtb-specific CD8+ cells that are neither HLA-A, B, or C nor group 1 CD1 restricted, and have found that these cells comprise the dominant CD8+ T cell response in latently infected individuals. In this report, three independent methods are used to demonstrate the ability of these cells to recognize Mtb-derived antigen in the context of the monomorphic HLA-E molecule. This is the first demonstration of the ability of HLA-E to present pathogen-derived antigen. Further definition of the HLA-E specific response may aid development of an effective vaccine against tuberculosis.