miR-491-5p functions as a tumor suppressor by targeting JMJD2B in ERα-positive breast cancer
miR-491-5p functions as a tumor suppressor by targeting JMJD2B in ERα-positive breast cancer
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miR-491-5p 通过靶向 ER α 阳性乳腺癌中的 JMJD2B 发挥肿瘤抑制因子的作用
DOI：
10.1016/j.febslet.2015.02.014
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发表时间：
2015-03-24
期刊：
影响因子：
3.5
通讯作者：
Li Hui
中科院分区：
文献类型：
--
作者：
Zeng Hui;Chen Yiling;Li Hui
miR-491- 5 p在乳腺癌发展中的作用尚不清楚。这项研究表明，miR-491- 5 p在ER α阳性乳腺癌组织和细胞系中显著下调，并且在ER α阳性乳腺癌中通常高甲基化。miR-491- 5 p过表达显著抑制雌激素信号传导和雌激素刺激的乳腺癌细胞增殖。此外，组蛋白去甲基化酶JMJD 2B被鉴定为miR-491- 5 p的直接靶点。JMJD 2B的异位表达消除了乳腺癌细胞中miR-491- 5 p诱导的表型变化。总之，我们的数据表明，miR-491- 5 p在乳腺癌的发生和发展中发挥肿瘤抑制作用，并可能成为ER α阳性乳腺癌的新的治疗靶点。(C)2015年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
The involvement of miR-491-5p in breast cancer development is unclear. This study showed that miR-491-5p is significantly downregulated in ER alpha-positive breast cancer tissues and cell lines and is generally hypermethylated in ER alpha-positive breast cancer. MiR-491-5p overexpression significantly suppressed estrogen signaling and estrogen-stimulated proliferation of breast cancer cells. Furthermore, the histone demethylase JMJD2B was identified as a direct target of miR-491-5p. The ectopic expression of JMJD2B abrogated the phenotypic changes induced by miR-491-5p in breast cancer cells. Collectively, our data indicate that miR-491-5p plays a tumor suppressor role in the development and progression of breast caner and may be a novel therapeutic target against ERa-positive breast cancer. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.