ALBUMINURIA IN TYPE-2 (NON-INSULIN-DEPENDENT) DIABETES-MELLITUS AND IMPAIRED GLUCOSE-TOLERANCE IN PIMA-INDIANS
ALBUMINURIA IN TYPE-2 (NON-INSULIN-DEPENDENT) DIABETES-MELLITUS AND IMPAIRED GLUCOSE-TOLERANCE IN PIMA-INDIANS
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DOI：
10.1007/bf00297452
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发表时间：
1989-12-01
期刊：
影响因子：
8.2
通讯作者：
KNOWLER, WC
中科院分区：
文献类型：
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作者：
NELSON, RG;KUNZELMAN, CL;KNOWLER, WC
异常尿白蛋白排泄的患病率，由尿白蛋白与肌酸酐的比率≥30 mg/g（大约相当于≥ 30 mg/g的白蛋白率）。30毫克/24小时），测定了2728年皮马印第安人年龄≥。来自亚利桑那州吉拉河印第安社区的15年，该社区是2型（非胰岛素依赖型）糖尿病患病率较高的人群。8%的糖耐量正常受试者、15%的糖耐量受损受试者和47%的糖尿病受试者存在白蛋白排泄过量。糖耐量受损患者中异常白蛋白尿的中等患病率表明，在某些受试者中，即使在低于糖尿病诊断水平的高血糖症也与肾脏异常相关，并且这些异常可能先于糖尿病发作。在患有糖尿病的皮马印第安人中，即使是那些最近发病的糖尿病患者，也经常观察到通常试纸法无法可靠检测到的异常白蛋白尿水平。发现与年龄、糖尿病病程、高血压水平、血压和胰岛素治疗有关。
The prevalence of abnormal urinary albumin excretion, defined by a urine albumin to creatinine ratio .gtoreq. 30 mg/g (approximately equivalent to an albumin rate of .gtoreq. 30 mg/24 h), was determined in 2728 Pima Indians aged .gtoreq. 15 years from the Gila River Indian Community in Arizona, a population with a high prevalence of Type 2 (non-insulin-dependent) diabetes mellitus. Excessive albumin excretion was present in 8% of subjects with normal glucose tolerance, 15% of those with impaired glucose tolerance, and 47% of subjects with diabetes. The intermediate prevalence of abnormal albuminuria in those with impaired glucose tolerance suggests that hyperglycaemia even at levels below those diagnostic of diabetes is associated with renal abnormalities in some subjects and that these abnormalities may precede the onset of diabetes. Abnormal albuminuria at levels not reliably detected by the usual dipstick methods was commonly observed in Pima Indians with diabetes, even those with diabetes of recent onset. Associations were found with age, duration of diabetes, level of glycaemia, blood pressure, and treatment with insulin.