Neuronal loss in hippocampus induced by prolonged ethanol consumption in rats.
Neuronal loss in hippocampus induced by prolonged ethanol consumption in rats.
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大鼠长期乙醇消耗引起海马神经元损失。
DOI：
10.1126/science.7394532
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发表时间：
1980
期刊：
影响因子：
56.9
通讯作者：
P. Kubanis
中科院分区：
文献类型：
--
作者：
D. W. Walker;D. Barnes;S. Zornetzer;B. Hunter;P. Kubanis
定量神经组织学技术被用来检查海马复合体的实验室大鼠保持含乙醇或控制饮食5个月，随后2个月的无酒精期。慢性乙醇消耗导致海马锥体和齿状回颗粒细胞的显着损失。这项研究提供了直接的证据表明，在没有营养不良的情况下，长期饮用乙醇会导致中枢神经系统的神经元损失。
Quantitative neurohistological techniques were used to examine the hippocampal complex of laboratory rats maintained on ethanol-containing or control diets for 5 months followed by a 2-month alcohol-free period. Chronic ethanol consumption resulted in a significant loss of hippocampal pyramidal and dentate gyrus granule cells. This study provides direct evidence that long-term ethanol consumption, in the absence of malnutrition, produces neuronal loss in the central nervous system.