The dynamic nuclear envelope: resilience in health and dysfunction in disease.
The dynamic nuclear envelope: resilience in health and dysfunction in disease.
复制标题
动态核膜：健康的恢复力和疾病的功能障碍。
DOI：
10.1016/j.ceb.2023.102230
复制
发表时间：
2023
影响因子：
7.5
通讯作者：
Ullman,KatharineS
中科院分区：
文献类型：
--
作者：
Turkmen,AyseM;Saik,NatashaO;Ullman,KatharineS
细胞核的典型外观取决于核被膜的不断适应和重塑，以响应不断变化的生物力学力和代谢需求。核膜的动态事件在支持关键核功能以及赋予该细胞器可塑性方面起着至关重要的作用。此外，这些动态过程的不平衡正在成为疾病病因学的中心特征。这篇评论的重点是最近的进展，揭示了无数的事件在核信封，有助于核结构的弹性和灵活性。
The canonical appearance of the nucleus depends on constant adaptation and remodeling of the nuclear envelope in response to changing biomechanical forces and metabolic demands. Dynamic events at the nuclear envelope play a vital role in supporting key nuclear functions as well as conferring plasticity to this organelle. Moreover, imbalance of these dynamic processes is emerging as a central feature of disease etiology. This review focuses on recent advances that shed light on the myriad events at the nuclear envelope that contribute to resilience and flexibility in nuclear architecture.