Targeting subchondral bone for treating osteoarthritis: what is the evidence?
Targeting subchondral bone for treating osteoarthritis: what is the evidence?
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DOI：
10.1016/j.berh.2009.08.004
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发表时间：
2010-02-01
影响因子：
5.2
通讯作者：
Martel-Pelletier, Johanne
中科院分区：
文献类型：
--
作者：
Tat, Steeve Kwan;Lajeunesse, Daniel;Martel-Pelletier, Johanne
在过去的几十年里，关于骨关节炎（OA）发病机制的新概念已经取得了重大进展。本文总结了一些知识，我们今天的参与软骨下骨在OA。它提供了大量的证据表明，软骨下骨代谢的变化是OA疾病过程的一个组成部分，这些变化不仅仅是继发性表现，而是疾病更活跃成分的一部分。因此，靶向软骨下骨吸收和/或形成的治疗方法存在很强的理论基础，并且评估靶向骨重塑的药物的数据提高了OA新治疗选择可能可用的希望。(C)2009爱思唯尔有限公司保留所有权利。
Over the past few decades, significant progress has been made with respect to new concepts about the pathogenesis of osteoarthritis (OA). This article summarises some of the knowledge we have today on the involvement of the subchondral bone in OA. It provides substantial evidence that changes in the metabolism of the subchondral bone are an integral part of the OA disease process and that these alterations are not merely secondary manifestations, but are part of a more active component of the disease. Thus, a strong rationale exists for therapeutic approaches that target subchondral bone resorption and/or formation, and data evaluating the drugs targeting bone remodelling raise the hope that new treatment options for OA may become available. (C) 2009 Elsevier Ltd. All rights reserved.