Calcium-Permeable Channels Cooperation for Rheumatoid Arthritis: Therapeutic Opportunities.
Calcium-Permeable Channels Cooperation for Rheumatoid Arthritis: Therapeutic Opportunities.
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钙渗透通道合作治疗类风湿关节炎：治疗机会
DOI：
10.3390/biom12101383
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发表时间：
2022-09-27
期刊：
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
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作者：
Rheumatoid arthritis is a common autoimmune disease that results from the deposition of antibodies–autoantigens in the joints, leading to long-lasting inflammation. The main features of RA include cartilage damage, synovial invasion and flare-ups of intra-articular inflammation, and these pathological processes significantly reduce patients’ quality of life. To date, there is still no drug target that can act in rheumatoid arthritis. Therefore, the search for novel drug targets has become urgent. Due to their unique physicochemical properties, calcium ions play an important role in all cellular activities and the body has evolved a rigorous calcium signaling system. Calcium-permeable channels, as the main operators of calcium signaling, are widely distributed in cell membranes, endoplasmic reticulum membranes and mitochondrial membranes, and mediate the efflux and entry of Ca2+. Over the last century, more and more calcium-permeable channels have been identified in human cells, and the role of this large family of calcium-permeable channels in rheumatoid arthritis has gradually become clear. In this review, we briefly introduce the major calcium-permeable channels involved in the pathogenesis of RA (e.g., acid-sensitive ion channel (ASIC), transient receptor potential (TRP) channel and P2X receptor) and explain the specific roles and mechanisms of these calcium-permeable channels in the pathogenesis of RA, providing more comprehensive ideas and targets for the treatment of RA.
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影响因子：
1.9
作者：
Baroja-Mazo A;Pelegrín P
通讯作者：
Pelegrín P
DOI：
10.1186/s12964-018-0280-8
发表时间：
2018-10-16
期刊：
Cell communication and signaling : CCS
影响因子：
--
作者：
Bai H;Zhu H;Yan Q;Shen X;Lu X;Wang J;Li J;Chen L
通讯作者：
Chen L
影响因子：
4.8
作者：
Chamoux, Estelle;Bisson, Martine;Roux, Sophie
通讯作者：
Roux, Sophie
影响因子：
6.1
作者：
ALM P E;BLOOM G D
通讯作者：
BLOOM G D
瞬态受体电位规范5（TRPC5）可预防关节炎和关节炎症中的疼痛和血管炎症。
影响因子：
27.4
作者：
Alawi KM;Russell FA;Aubdool AA;Srivastava S;Riffo-Vasquez Y;Baldissera L Jr;Thakore P;Saleque N;Fernandes ES;Walsh DA;Brain SD
通讯作者：
Brain SD