The Role of Ortho-dearomatization Reaction in Constructing Spirocyclic Scaffolds with an All-carbon Ring Junction
The Role of Ortho-dearomatization Reaction in Constructing Spirocyclic Scaffolds with an All-carbon Ring Junction
复制标题
邻位脱芳基反应在构建全碳环连接的螺环支架中的作用
DOI：
10.2174/1570179415666180720110051
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发表时间：
2018-10
影响因子：
1.8
通讯作者：
Chao Zheng
中科院分区：
文献类型：
--
作者：
Lili Shi;Wenge Zhang;Shou Chen;Lele Lu;Rong Fan;Jiajing Tan;Chao Zheng
螺环骨架是天然产物中一种重要的结构基序，通常是其复杂结构和显著生物学特性的原因。近期的研究进展表明，多种情况都有望用于其构建。
Spiro skeleton is an important structural motif in natural products, usually accounting
for their formidable architectures and remarkable biological profiles. Recent advances demonstrated that a diverse
range of scenarios held the promise for the assembly of spirocenter based on ortho-dearomatization strategy.
In this article, we describe the latest development of ortho-dearomatization reaction in constructing spirocyclic
scaffolds with an all-carbon ring junction from a methodological standpoint.
The review focuses on recent progress in the area of ortho-dearomatization reaction in constructing
spirocyclic scaffolds with an all-carbon ring junction.
In summary, we have summarized the capability of ortho-dearomatization reaction to construct
spirocyclic skeleton, a common structural pattern found at the core of numerous natural products with broad
structural diversities and important bioactivities. Success in this area will benefit not only the area of synthetic
chemistry through methodological development, but also medicinal chemistry and chemical biology by providing
access to rapid assembly of bioactive compounds’ core scaffolds.