PREVALENCE OF CAROTID ATHEROSCLEROSIS AND SERUM-CHOLESTEROL LEVELS IN EASTERN FINLAND
PREVALENCE OF CAROTID ATHEROSCLEROSIS AND SERUM-CHOLESTEROL LEVELS IN EASTERN FINLAND
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DOI：
10.1161/01.atv.8.6.788
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发表时间：
1988-11-01
期刊：
影响因子：
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通讯作者：
SALONEN, JT
中科院分区：
文献类型：
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作者：
SALONEN, R;SEPPANEN, K;SALONEN, JT
我们调查了1987年2月至12月Kuopio缺血性心脏病危险因素研究中412名年龄为42、48、54或60岁的东芬兰男性颈动脉粥样硬化的患病率及其与血清脂蛋白胆固醇含量的关系。采用高分辨率b超评估动脉粥样硬化。在参与者中，37%的人有动脉内膜或内层增厚，10%的人有斑块，2%的人在右或左颈总动脉或颈动脉分叉处有狭窄，只有51%的人没有任何可检测到的颈动脉粥样硬化。四个年龄组的动脉粥样硬化患病率分别为14.1%、32.0%、67.7%和81.9%。无颈动脉粥样硬化男性的平均年龄调整血清低密度脂蛋白（LDL）胆固醇浓度为3.67 mmol/l (142 mg/dl)，至少有内膜增厚的男性的平均年龄调整血清低密度脂蛋白（LDL）胆固醇浓度为4.02 mmol/l (155 mg/dl) （p = 0.003）。无动脉粥样硬化男性的平均年龄校正血清高密度脂蛋白（HDL）浓度为1.34 mmol/l (52 mg/dl)，动脉粥样硬化男性的平均年龄校正血清胆固醇浓度为1.27 mmol/l (49 mg/dl) （p = 0.029）。在血清HDL2和HDL3胆固醇水平上也有类似的差异。在一个调整了年龄、肥胖、血浆纤维蛋白原、吸烟年限和高血压持续时间的多元回归模型中，血清LDL和HDL（逆）胆固醇是颈动脉粥样硬化严重程度的重要决定因素。我们的数据揭示了东芬兰中年男性动脉粥样硬化的高患病率，并为LDL和HDL胆固醇在动脉粥样硬化中的作用提供了进一步的证据。
We investigated the prevalence of carotid atherosclerosis and its association with serum lipoprotein cholesterol fractions in 412 Eastern Finnish men ages 42, 48, 54, or 60 years who were examined between February and December 1987 in the Kuopio Ischaemic Heart Disease Risk Factor Study. Cartoid atherosclerosis was assessed with high-resolution B-mode ultrasonography. Of the participants, 37% had thickening of the intimal or medial layer of the arterial wall, 10% had plaques, 2% had stenosis in the right or left common carotid artery or in the carotid bifurcation, and only 51% were free of any detectable carotid atherosclerosis. The prevalence of atherosclerosis was 14.1%, 32.0%, 67.7%, and 81.9% in the four age groups, respectively. The mean age-adjusted serum low density lipoprotein (LDL) cholestrol concentration was 3.67 mmol/l (142 mg/dl) in men free of carotid atherosclerosis and 4.02 mmol/l (155 mg/dl) in those with at least intimal thickening (p = 0.003 for difference). The mean age-adjusted serum cholesterol concentration in the high density lipoprotein (HDL) fraction was 1.34 mmol/l (52 mg/dl) in the atherosclerosis free and 1.27 mmol/l (49 mg/dl) in the atherosclerotic men (p = 0.029 for difference). There was a similar difference in both the serum HDL2 and the HDL3 cholesterol levels. Serum LDL and HDL (inverse) cholesterol were significant determinants of severity of carotid atherosclerosis in a multivariate regression model adjusting for age, obesity, plasma fibrinogen, cigarette-years, and duration of hypertension. Our data reveal the high prevalence of atherosclerosis in middle-aged Eastern Finnish men and provide further evidence of the roles of LDL and HDL cholesterol in atherosclerosis.