Selective C-F Bond Activation of Tetrafluorobenzenes by Nickel(0) with a Nitrogen Donor Analogous to N-Heterocyclic Carbenes
Selective C-F Bond Activation of Tetrafluorobenzenes by Nickel(0) with a Nitrogen Donor Analogous to N-Heterocyclic Carbenes
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DOI：
10.1002/anie.200806048
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发表时间：
2009-01-01
影响因子：
16.6
通讯作者：
Johnson, Samuel A.
中科院分区：
文献类型：
--
作者：
Doster, Meghan E.;Johnson, Samuel A.
N，非NHC：开发了一种中性、碱性、强σ-供体氮辅助配体，其性质类似于N-杂环卡宾（NHC），以帮助将挑战性底物氧化加成到后过渡金属。在该供体的存在下，使用镍（0）源，观察到六氟苯、五氟苯和所有三种四氟苯异构体的选择性室温C F键活化。
N, not NHC: A neutral, basic, strong σ‐donor nitrogen ancillary ligand with properties analogous to those of N‐heterocyclic carbenes (NHCs) was developed to aid in the oxidative additions of challenging substrates to late transition metals. Selective, room‐temperature CF bond activation was observed with hexa‐, penta‐, and all three isomers of tetrafluorobenzene using a nickel(0) source in the presence of this donor.