Cycloxygeroase-2 expression correlates with local chronic inflammation and tumor neovascularization in human prostate cancer
Cycloxygeroase-2 expression correlates with local chronic inflammation and tumor neovascularization in human prostate cancer
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DOI：
10.1158/1078-0432.ccr-04-2405
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发表时间：
2005-05-01
影响因子：
11.5
通讯作者：
Damber, JE
中科院分区：
文献类型：
--
作者：
Wang, WZ;Bergh, A;Damber, JE
目的：慢性炎症与包括前列腺癌在内的多个器官的癌症的发展有关。上调的环氧合酶-2(COX-2)可能在影响细胞的增殖、分化、凋亡或血管生成中发挥作用。本研究旨在探讨慢性炎症和血管生成是否与COX-2的表达有关。实验设计：本研究采用双重免疫组织化学方法检测43例前列腺癌组织中COX-2的表达及其与T淋巴细胞、巨噬细胞密度和CD31标记的微血管密度(MVD)的关系。结果：43例前列腺癌组织中有40例COX-2阳性表达。COX-2高表达与Gleason评分高相关(P=0.002)。43例标本均可见慢性炎症灶。COX-2阳性区T淋巴细胞和巨噬细胞密度高于COX-2阴性区(P<0.0001和P=0.001)。COX-2表达阳性的肿瘤组织中微血管密度也高于COX-2表达阴性的肿瘤组织(P=0.001)。结论：COX-2表达与前列腺癌局部慢性炎症及血管生成增加之间存在新的关系。T淋巴细胞和巨噬细胞释放的炎性细胞因子可能上调邻近肿瘤细胞中COX-2的表达，刺激间质组织中的血管生成。这些发现表明，COX-2可能是前列腺癌治疗的有效靶点。
Purpose: Chronic inflammation is linked to the development of cancer in several organs, including the prostate. Up-regulated cyclooxygenase-2 (COX-2) may play a role in influencing cell proliferation, differentiation, apoptosis, or angiogenesis. This study aimed to derive data from human prostate cancer to investigate whether chronic inflammation and angiogenesis were correlated with the expression of COX-2.Experimental Design: In this study, we did double-immunohistochemical analysis of a set of 43 human prostate cancer for COX-2 expression and the correlation with T-lymphocyte and macrophage densities and CD31-marked microvessel density (MVD) in situ.Results: COX-2 positive staining was detected in 40/43 cancer samples with the very heterogeneous expression. Elevated COX-2 expression was associated with high Gleason score (P = 0.002). Foci of chronic inflammation were found in all 43 samples. COX-2-positive areas were noted with high T-lymphocyte and macrophage densities than COX-2-negative tumor areas (P < 0.0001 and P = 0.001, respectively). MVD were also found higher in COX-2-positive areas than in COX-2-negative tumor areas (P = 0.001).Conclusions: This study shows a novel relationship between COX-2 expression and the local chronic inflammation within prostate cancer and the increased angiogenesis. It is likely that the proinflmmatory cytokines, released by T-lymphocytes and macrophages, up-regulate COX-2 in adjacent tumor cells and stimulate the angiogenesis in stromal tissues. These findings suggest that COX-2 may be an effective therapeutic target in prostate cancer treatment.