Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection
Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection
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DOI：
10.1016/j.bmcl.2005.09.039
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发表时间：
2006-01-01
影响因子：
2.7
通讯作者：
Stachlewitz, RF
中科院分区：
文献类型：
--
作者：
Burchat, A;Borhani, DW;Stachlewitz, RF
在实体器官移植排斥反应模型中，我们描述了src家族选择性ICK抑制剂A-770041延长主要组织相容性不匹配同种异体移植物存活超过65天的鉴定、合成孔径反应和药理学。(C)2005爱思唯尔有限公司。保留所有权利。
We describe the identification, SAR, and pharmacology of the src-family selective Ick inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days. (c) 2005 Elsevier Ltd. All rights reserved.