Altered Inhibitory Modulation of Somatosensory Cortices in Paroxysmal Kinesigenic Dyskinesia
Altered Inhibitory Modulation of Somatosensory Cortices in Paroxysmal Kinesigenic Dyskinesia
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DOI：
10.1002/mds.25656
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发表时间：
2013-10-01
影响因子：
8.6
通讯作者：
Lin, Yung-Yang
中科院分区：
文献类型：
--
作者：
Hsu, Wan-Yu;Kwan, Shang-Yeong;Lin, Yung-Yang
BackgroundThe的目的，这项研究是为了澄清的兴奋性配置文件的躯体感觉皮层在患者阵发性运动诱发性运动障碍。MethodsWhole-head magnetoencephalography被用来记录躯体感觉诱发领域引起的配对脉冲电刺激正中神经在15例阵发性运动诱发性运动障碍和对照组的18名年龄匹配，健康志愿者。12例患者进行了研究，在药物关闭和药物onstate.ResultsThe配对脉冲抑制率的初级体感皮层P35 m反应和次级体感皮层反应的药物关闭患者阵发性运动诱发性运动障碍相比，无论是药物上的患者或对照组显着更大。配对脉冲抑制率无显着差异，观察药物对患者与阵发性运动诱发性运动障碍和control group.ConclusionsIn患者阵发性运动诱发性运动障碍，皮质内抑制的初级和次级躯体感觉皮质区受损，相关的过度兴奋现象是可调制的抗癫痫药物。(c)2013年国际帕金森和运动障碍协会
BackgroundThe objective of this study was to clarify the excitability profiles of the somatosensory cortices in patients with paroxysmal kinesigenic dyskinesia.MethodsWhole-head magnetoencephalography was used to record the somatosensory evoked fields elicited by paired-pulse electric stimulation of the median nerve in 15 patients with paroxysmal kinesigenic dyskinesia and in a control group of 18 age-matched, healthy volunteers. Twelve of the patients were studied in both the drug-off and drug-on state.ResultsThe paired-pulse inhibition ratios of the primary somatosensory cortical P35m responses and the secondary somatosensory cortical responses were significantly greater in drug-off patients with paroxysmal kinesigenic dyskinesia compared with either the drug-on patients or the control group. No significant difference in paired-pulse inhibition ratio was observed between the drug-on patients with paroxysmal kinesigenic dyskinesia and the control group.ConclusionsIn patients with paroxysmal kinesigenic dyskinesia, intracortical inhibition of the primary and secondary somatosensory cortical areas is impaired, and the associated hyperexcitable phenomenon is modulatable by antiepileptic drugs. (c) 2013 International Parkinson and Movement Disorder Society