Mexican American ancestry-informative markers: Examination of population structure and marker characteristics in European Americans, Mexican Americans, Amerindians and Asians
Mexican American ancestry-informative markers: Examination of population structure and marker characteristics in European Americans, Mexican Americans, Amerindians and Asians
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DOI：
10.1007/s00439-003-1058-6
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发表时间：
2004-02-01
期刊：
影响因子：
5.3
通讯作者：
Seldin, MF
中科院分区：
文献类型：
--
作者：
Collins-Schramm, HE;Chima, B;Seldin, MF
不同种族间等位基因频率差异较大的标记提供了可应用于遗传研究的祖先信息。我们确定了100多个双等位基因祖先信息标记（AIM）与大的等位基因频率差异之间的欧洲裔美国人（EA）和皮马美洲印第安人从实验室和数据库屏幕。对于35个这些标记，玛雅人，Yavapai和Quechuan美洲印第安人进行基因分型，并与EA和Pima等位基因频率进行比较。EA和一个美洲印第安部落之间等位基因频率差异较大的标记在美洲印第安部落之间只有很小的差异。对个体结构的研究表明，欧洲人与美洲印第安人血统的个体之间存在明显的分离，而来自不同美洲印第安人群体的个体之间存在相似性。AIM显示了墨西哥裔美国人个体祖先组成的变化，提供了混合物映射和控制关联测试结构的适用性证据。此外，高比例的单核苷酸多态性（SNPs）的基础上选择EA和亚洲人群之间的大频率差异有很大的等位基因频率差异EA和美洲印第安人，这表明一个有效的方法，大大扩大AIM用于混合映射/结构分析在墨西哥裔美国人。总之，这些数据提供了额外的支持混合映射在墨西哥裔美国人的实际应用。
Markers with large differences in allele frequencies between ethnicities provide ancestry information that can be applied to genetic studies. We identified over 100 biallelic ancestry informative markers (AIMs) with large allele frequency differences between European Americans (EA) and Pima Amerindians from laboratory and database screens. For 35 of these markers, Mayan, Yavapai and Quechuan Amerindians were genotyped and compared with EA and Pima allele frequencies. Markers with large allele frequency differences between EA and one Amerindian tribe showed only small differences between the Amerindian tribes. Examination of structure in individuals demonstrated a clear separation of subjects of European from those of Amerindian ancestry, and similarity between individuals from disparate Amerindian populations. The AIMs demonstrated the variation in ancestral composition of individual Mexican Americans, providing evidence of applicability in admixture mapping and in controlling for structure in association tests. In addition, a high percentage of single-nucleotide polymorphisms (SNPs) selected on the basis of large frequency differences between EA and Asian populations had large allele frequency differences between EA and Amerindians, suggesting an efficient method for greatly expanding AIMs for use in admixture mapping/structure analysis in Mexican Americans. Together, these data provide additional support for the practical application of admixture mapping in the Mexican American population.