Diabetic ketoacidosis at type 1 diabetes diagnosis in children during the COVID-19 pandemic
Diabetic ketoacidosis at type 1 diabetes diagnosis in children during the COVID-19 pandemic
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DOI：
10.1111/pedi.13205
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发表时间：
2021-03-27
影响因子：
3.4
通讯作者：
Doulla, Manpreet
中科院分区：
文献类型：
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作者：
Ho, Josephine;Rosolowsky, Elizabeth;Doulla, Manpreet
目的新冠肺炎大流行导致了重大的公共卫生措施，导致急性儿科护理利用率下降。我们评估了自新冠肺炎公共卫生措施颁布以来，新发1型糖尿病(DM1)严重表现的比率是否发生了变化。研究设计与方法对加拿大艾伯塔省两家三级保健儿科医院2020年3月17日至2020年8月31日期间新发DM1的年龄小于18岁的儿童进行了回顾性图表回顾。结果2020年大流行年新诊断为DM1的儿童人数与2019年相比相似(2020年为107人，2019年为114人)。大流行期间新发DM1的DKA发生率显著高于流行期间(68.2%vs 45.6%；p<；0.001)，重度DKA的发生率也较高(2020年27.1%vs 2019年13.2%；p=0.001)。这强调了需要教育卫生保健专业人员和家庭认识到高血糖的症状，以及即使在新冠肺炎采取公共卫生措施期间也要及早诊断和治疗的重要性。
Objective The COVID-19 pandemic has led to significant public health measures that have resulted in decreased acute pediatric care utilization. We evaluated whether the rate of severe presentations of new onset type 1 diabetes (DM1), such as, diabetic ketoacidosis (DKA) has changed since the COVID-19 public health measures were enacted.Research Design and Methods A retrospective chart review of children less than 18 years of age presenting with new onset DM1 during the pandemic period of March 17, 2020 to August 31, 2020 was conducted at two tertiary care pediatric hospitals in Alberta, Canada. Rates of DKA and severe DKA were compared to the same time period in the year 2019 (pre-pandemic control).Results The number of children presenting with newly diagnosed DM1 was similar during the pandemic year of 2020 compared with 2019 (107 children in 2020 vs. 114 in 2019). The frequency of DKA at DM1 onset was significantly higher in the pandemic period (68.2% vs 45.6%; p < 0.001) and incidence of severe DKA was also higher (27.1% in 2020 vs 13.2% in 2019; p = 0.01).Conclusions There was a significant increase in DKA and severe DKA in children presenting with new onset DM1 during the COVID-19 pandemic period. This emphasizes the need for educating health care professionals and families to be aware of the symptoms of hyperglycemia and the importance of early diagnosis and treatment even during public health measures for COVID-19.