Being breastfed in infancy and adult breast cancer risk among Japanese women
Being breastfed in infancy and adult breast cancer risk among Japanese women
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DOI：
10.1007/s10552-011-9888-3
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发表时间：
2012-02-01
影响因子：
2.3
通讯作者：
Kakugawa, Yoichiro
中科院分区：
文献类型：
--
作者：
Minami, Yuko;Nishino, Yoshikazu;Kakugawa, Yoichiro
目的 据推测，婴儿期母乳喂养会影响随后患乳腺癌的风险。在一项以医院为基础的病例对照研究中，我们调查了不同出生年份的女性受试者中母乳喂养与乳腺癌风险之间的整体和单独关系。方法研究对象包括 1997 年至 2005 年间在日本宫城县一家医院收治的 571 例病例和 2,155 名对照组。通过自填问卷评估母乳喂养史。使用逻辑回归估计优势比 (OR) 和 95% 置信区间 (CI)。结果 在调整已知风险因素后，总体上未观察到母乳喂养与母乳喂养之间的关联（OR = 1.20；95% CI：0.82-1.76）。根据出生年份 (= 1950) 分层的分析表明，两个出生年份组之间母乳喂养的关联性存在异质性（交互作用 p = 0.0006）；在 1950 年之前出生的受试者中，母乳喂养与风险降低显着相关（OR = 0.59；95% CI：0.35-0.99），而 1950 年之后出生的受试者则没有观察到这种风险降低（OR = 1.60；95% CI：0.88-2.90）。结论 虽然母乳喂养与总体风险无关，但出生年份可能会改变母乳喂养与母乳喂养之间的关联。婴儿期母乳喂养和乳腺癌风险。在日本，自二战结束以来，社会人口发生了变化。标准配方奶粉补充剂的使用在 1950 年左右开始普及。不同出生年份人群患乳腺癌风险的差异可能归因于这些环境变化。
Objective Being breastfed in infancy has been hypothesized to influence subsequent breast cancer risk. In a hospital-based case-control study, we investigated the relationship between having been breastfed and breast cancer risk, both overall and separately among female subjects with different birth years.Methods The study subjects included 571 cases and 2,155 controls admitted to a single hospital in Miyagi Prefecture, Japan, between 1997 and 2005. History of having been breastfed was assessed with a self-administered questionnaire. Odds ratios (ORs) and 95% confidence interval (CI) were estimated using logistic regression.Results After adjustment for known risk factors, no association for having been breastfed was observed overall (OR = 1.20; 95% CI: 0.82-1.76). Analysis stratified according to birth year (= 1950) demonstrated heterogeneity in the association for having been breastfed between the two birth-year groups (p for interaction = 0.0006); having been breastfed was significantly associated with a decreased risk among subjects who were born before 1950 (OR = 0.59; 95% CI: 0.35-0.99), whereas no such risk reduction was observed for subjects born after 1950 (OR = 1.60; 95% CI: 0.88-2.90).Conclusion Although having been breastfed is not related to overall risk, birth year may modify the association between having been breastfed in infancy and breast cancer risk. In Japan, sociodemographic changes have occurred since the end of World War II. The use of standard formula supplement began to spread around 1950. The difference of breast cancer risk between birth-year groups may be attributable to these environmental changes.