Influence of Ketamine–Xylazine Anaesthesia on Cubic and Quadratic High-Frequency Distortion-Product Otoacoustic Emissions
Influence of Ketamine–Xylazine Anaesthesia on Cubic and Quadratic High-Frequency Distortion-Product Otoacoustic Emissions
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氯胺酮赛拉嗪麻醉对三次和二次高频失真产物耳声发射的影响
DOI：
10.1007/s10162-014-0470-z
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Kössl M
中科院分区：
文献类型：
--
作者：
Schlenther D;Voss C;Kössl M
氯胺酮是一种解离性麻醉、镇痛药物，也是一种ann -甲基-d-天冬氨酸受体拮抗剂，据报道可影响耳声发射振幅。在本研究中，我们评估了氯胺酮-噻嗪对蝙蝠高频失真产物耳声发射（DPOAE）的影响，该模型作为敏感高频听力的模型。三次DPOAE提供了有关人工耳蜗放大器非线性增益的信息，而二次DPOAE用于评估人工耳蜗放大的对称性和潜在的传出对人工耳蜗放大器工作状态的影响。麻醉期间，在35 - 60 dB声级的中等刺激水平范围内，最大立方DPOAE水平可增加35 dB。在接近-10 dB声压级阈值时，当刺激水平低于约20-30 dB声压级时，麻醉会降低立方DPOAE振幅并提高立方DPOAE阈值。这使得DPOAE的增长函数更陡峭。此外，氯胺酮增加最佳刺激频率比，这是耳蜗调谐锐度降低的指示。氯胺酮对立方DPOAE阈值的影响在更高的刺激频率下变得更强，并且在超过40 kHz的f2频率上非常显著。在中等刺激水平下，氯胺酮可使二次DPOAE水平提高25 dB。与三次DPOAE相比，二次DPOAE阈值的变化是可变的，麻醉期间没有明显的敏感性丧失。我们讨论氯胺酮效应可能是由中耳功能的调节或同侧传出调制的释放引起的，这主要影响耳蜗放大的增益。
Ketamine is a dissociative anaesthetic, analgesic drug as well as anN-methyl-d-aspartate receptor antagonist and has been reported to influence otoacoustic emission amplitudes. In the present study, we assess the effect of ketamine–xylazine on high-frequency distortion-product otoacoustic emissions (DPOAE) in the bat speciesCarollia perspicillata, which serves as model for sensitive high-frequency hearing. Cubic DPOAE provide information about the nonlinear gain of the cochlear amplifier, whereas quadratic DPOAE are used to assess the symmetry of cochlear amplification and potential efferent influence on the operating state of the cochlear amplifier. During anaesthesia, maximum cubic DPOAE levels can increase by up to 35 dB within a medium stimulus level range from 35 to 60 dB SPL. Close to the -10 dB SPL threshold, at stimulus levels below about 20-30 dB SPL, anaesthesia reduces cubic DPOAE amplitudes and raises cubic DPOAE thresholds. This makes DPOAE growth functions steeper. Additionally, ketamine increases the optimum stimulus frequency ratio which is indicative of a reduction of cochlear tuning sharpness. The effect of ketamine on cubic DPOAE thresholds becomes stronger at higher stimulus frequencies and is highly significant for f2 frequencies above 40 kHz. Quadratic DPOAE levels are increased by up to 25 dB by ketamine at medium stimulus levels. In contrast to cubic DPOAEs, quadratic DPOAE threshold changes are variable and there is no significant loss of sensitivity during anaesthesia. We discuss that ketamine effects could be caused by modulation of middle ear function or a release from ipsilateral efferent modulation that mainly affects the gain of cochlear amplification.
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影响因子：
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作者：
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DOI：
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发表时间：
1993
期刊：
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影响因子：
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影响因子：
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作者：
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