Killing capacity of human polymorphonuclear leukocytes in aerobic and anaerobic conditions.
Killing capacity of human polymorphonuclear leukocytes in aerobic and anaerobic conditions.
复制标题
人多形核白细胞在有氧和厌氧条件下的杀伤能力。
DOI：
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发表时间：
1984
影响因子：
3
通讯作者：
D. Maclaren
中科院分区：
文献类型：
--
作者：
W. Vel;F. Namavar;A. Verweij;A. Pubben;D. Maclaren
在体外需氧和厌氧条件下，研究了人多形核白细胞对几种细菌（其中一些为过氧化氢酶阳性）的杀伤作用。当除氧张力以外的所有条件相同时，30分钟后的杀灭在有氧条件下比在厌氧条件下略大。然而，在60和120分钟后，需氧和厌氧杀灭之间的差异较小，并且对所有测试菌株几乎完全杀灭。这些结果与普遍认为氧气是有效杀人所必需的观点相矛盾。实验条件的微小差异可能会极大地影响结果，并可能导致本研究与以前关于该主题的一些研究之间的差异。
The killing by human polymorphonuclear leukocytes of several species of bacteria, some of which were catalase positive, was examined in vitro in aerobic and anaerobic conditions. When all conditions other than the oxygen tension were identical, killing after 30 min was slightly greater in aerobic than in anaerobic conditions. However, after 60 and 120 min the difference between aerobic and anaerobic killing was smaller, and killing was nearly complete for all strains tested. These results conflict with the common opinion that oxygen is essential for efficient killing. Minor differences in experimental conditions can greatly influence results, and may be responsible for the discrepancy between this study and some previous studies on this subject.