Association between Serum Biomarkers with Postoperative Complications and Delay of Adjuvant Chemotherapy Initiation in Ovarian Cancer Patients Undergoing Primary Cytoreductive Surgery: A Pilot Study.
Association between Serum Biomarkers with Postoperative Complications and Delay of Adjuvant Chemotherapy Initiation in Ovarian Cancer Patients Undergoing Primary Cytoreductive Surgery: A Pilot Study.
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血清生物标志物与接受初次细胞减灭术的卵巢癌患者术后并发症和辅助化疗开始延迟之间的关联：一项试点研究。
DOI：
10.1080/01635581.2022.2152060
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Holman,LauraL
中科院分区：
文献类型：
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作者：
Ade,CarlJ;Dockery,Lauren;Walter,AdamC;Benbrook,DorisM;Vesely,SaraK;Hammond,StephenT;Moore,KathleenN;Holman,LauraL
本研究试图描述和关联的因素与并发症和延迟辅助化疗的卵巢癌患者接受原发性肿瘤细胞减灭术治疗。分析了计划接受初次细胞减灭术的卵巢癌患者的血清中前白蛋白、25-OH维生素D、细胞内粘附分子1（ICAM-1）、白细胞介素6（IL-6）、白细胞介素8（IL-8）、单核细胞趋化蛋白1（MCP-1）、单核细胞趋化蛋白2（MCP-2）、巨噬细胞衍生趋化因子（MDC）。使用术后4.0天和30天不良事件的通用术语标准确定术后并发症。辅助化疗延迟定义为手术和开始之间的间隔>1周。有术后并发症的患者（39.6%）年龄明显较大，血清前白蛋白水平较低，血清IL-6和IL-8水平高于无并发症的患者。单因素Logistic回归分析发现年龄（OR：1.12，95%CI：1.00-1.35）和IL-6（OR：1.02，95%CI：0.99-1.05）与术后并发症相关，而多因素分析后年龄仍有显著性（OR：1.14，95%CI：1.00-1.29）。延迟化疗的患者比未延迟化疗的患者表现出更高的BMI和更低的25-OH维生素D。多变量分析发现，在控制年龄、体重指数和肿瘤分级后，25-OH维生素D水平的增加与延迟化疗开始的风险降低相关（OR：0.93，95%CI：0.87-0.99）。这项工作表明，除了年龄是术后并发症的预测，血清25-OH维生素D可以提供洞察病人的风险手术后化疗开始延迟。然而，这些发现应该在更大的研究中得到证实，包括强大的生存分析。
This study sought to describe and relate the factors associated with complications and delays in adjuvant chemotherapy in patients with ovarian cancer treated with primary cytoreductive surgery. Serum from patients diagnosed with ovarian cancer scheduled for primary cytoreductive surgery were analyzed for prealbumin, 25-OH Vitamin D, intracellular adhesion molecule 1 (ICAM-1), interleukin 6 (IL-6), interleukin 8 (IL-8), monocyte chemoattractant protein 1 (MCP-1), monocyte chemoattractant protein 2 (MCP-2), macrophage derived chemokine (MDC). Postoperative complications were identified using common terminology criteria for adverse events 4.0 and 30 day after surgery. Delays in adjuvant chemotherapy were defined as >1 week interval between surgery and initiation. Patients with postoperative complications (39.6%) were significantly older, had lower serum prealbumin levels, and higher serum IL-6 and IL-8 than those without. Univariate logistic regression found that age (OR: 1.12, 95%CI: 1.00-1.35) and IL-6 (OR: 1.02, 95%CI: 0.99-1.05) were associated with postoperative complications, whereas age remained significant after multivariate analysis (OR:1.14, 95%CI: 1.00-1.29). Patients with delays in chemotherapy exhibited greater BMI and lower 25-OH Vitamin D than those without. Multivariate analysis found that increasing levels of 25-OH Vitamin D were associated with a lower risk of delayed chemotherapy initiation after controlling for age, body mass index, and tumor grade (OR: 0.93, 95%CI:0.87-0.99). This work suggests that in addition to age being predictive of postoperative complications, serum 25-OH Vitamin D may a provide insight into a patient’s risk for postsurgical delays in chemotherapy initiation. These findings should, however, be confirmed in a larger study including robust survival analysis.