Differential expression of ryanodine receptor in the developing rat cochlea.
Differential expression of ryanodine receptor in the developing rat cochlea.
复制标题
发育中的大鼠耳蜗中兰尼碱受体的差异表达。
DOI：
10.4081/ejh.2009.e30
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发表时间：
2009-12-29
期刊：
影响因子：
--
通讯作者：
Yang J
中科院分区：
文献类型：
--
作者：
Liang Y;Huang L;Yang J
Ryanodine receptors (RyRs) are one of the intracellular calcium channels involved in regulation of intracellular free calcium concentration ([Ca2+]i). The immunolocalization of RyRs was investigated in the developing rat cochlea at different postnatal days (PND). The change of [Ca2+]i in isolated outer hair cells (OHCs) was determined. Morphological results showed low expression of RyRs in the Kolliker’s organ from the PND 5 group. RyR expression in inner hair cells (IHCs) increased as the rats aged, and was mature after PND 14. RyRs in OHCs were expressed near the synaptic area of afferent and efferent nerves. RyRs in supporting cells were expressed widely and strongly. The application of ACh, ryanodine + ACh, and thapsigargin + ACh could induce a significant increase in [Ca2+]i in OHCs in the presence of extracellular calcium. This increase of [Ca2+]i induced by ACh was caused by not only the calcium influx through surface calcium channels, but also the calciuminduced calcium release (CICR) from intracellular RyR-sensitive calcium stores. Morphological and Ca imaging results suggested that RyRs expression is related to cochlear maturity, and may play an important role in its function.
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影响因子：
16.2
作者：
Beutner, D;Voets, T;Moser, T
通讯作者：
Moser, T
影响因子：
4
作者：
Evans, MG;Lagostena, L;Mammano, F
通讯作者：
Mammano, F
影响因子：
9.2
作者：
Gale, JE;Piazza, V;Mammano, F
通讯作者：
Mammano, F
影响因子：
1.4
作者：
Sato, Y;Handa, T;Orita, Y
通讯作者：
Orita, Y
影响因子：
3.4
作者：
Beurg, M;Hafidi, A;Dulon, D
通讯作者：
Dulon, D