Generalized Myasthenia Gravis: Classification, Clinical Presentation, Natural History, and Epidemiology
Generalized Myasthenia Gravis: Classification, Clinical Presentation, Natural History, and Epidemiology
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DOI：
10.1016/j.ncl.2018.01.002
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发表时间：
2018-05-01
影响因子：
2.4
通讯作者：
Silvestri, Nicholas J.
中科院分区：
文献类型：
--
作者：
Hehir, Michael K.;Silvestri, Nicholas J.
重症肌无力（MG）是一种罕见的疾病，但最常见的神经肌肉接头疾病。它是最常见的原型自身免疫性疾病，由乙酰胆碱受体（AChR）抗体引起，导致眼部、延髓、呼吸、中轴和四肢肌肉的特征性疲劳性无力。大多数MG患者首先出现眼部症状。大多数MG患者在整个病程中至少经历1次症状加重。这篇文章涵盖了MG的流行病学、临床表现、分类和自然史。
Myasthenia gravis (MG) is a rare disease but the most common disorder of the neuromuscular junction. It is the prototypic autoimmune disease most commonly caused by antibodies to the acetylcholine receptor (AChR) leading to characteristic fatigable weakness of the ocular, bulbar, respiratory, axial, and limb muscles. The majority of patients with MG first present with ocular symptoms. Most patients with MG experience at least 1 exacerbation of symptoms throughout the course of their illness. This article covers the epidemiology, clinical presentation, classification, and natural history of MG.