Retrospective analysis of the use of cyclosporine in myasthenia gravis
Retrospective analysis of the use of cyclosporine in myasthenia gravis
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DOI：
10.1212/wnl.55.3.448
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发表时间：
2000-08-08
期刊：
影响因子：
9.9
通讯作者：
Sanders, DB
中科院分区：
文献类型：
--
作者：
Ciafaloni, E;Nikhar, NK;Sanders, DB
作者回顾了1987年11月至1999年1月期间服用环孢素至少6个月的重症肌无力患者的记录。57例患者平均服用环孢素3.5年，55例（96%）临床改善。达到最佳临床反应的中位时间为7个月。在38名服用皮质类固醇的患者中，95%的患者停用或减少了皮质类固醇的使用。主要副作用包括血清肌酐升高（28%）和恶性肿瘤（11%）。5%的人负担不起或无法忍受这种药物。
The authors reviewed the records of patients with myasthenia gravis who took cyclosporine for at least 6 months between November 1987 and January 1999. Of 57 patients who took cyclosporine for an average of 3.5 years, 55 (96%) had clinical improvement. The median time to best clinical response was 7 months. Corticosteroids were discontinued or decreased in 95% of 38 patients taking them. Major side effects included elevated serum creatinine (28%) and malignancy (11%). Five percent could not afford or tolerate the drug.