Serotonin receptor 2c-expressing cells in the ventral CA1 control attention via innervation of the Edinger-Westphal nucleus
Serotonin receptor 2c-expressing cells in the ventral CA1 control attention via innervation of the Edinger-Westphal nucleus
复制标题
腹侧 CA1 中表达血清素受体 2c 的细胞通过 Edinger-Westphal 核的神经支配控制注意力。
DOI：
10.1038/s41593-018-0207-0
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发表时间：
2018-09-01
影响因子：
25
通讯作者：
Lu, Youming
中科院分区：
文献类型：
--
作者：
Li, Xinyan;Chen, Wenting;Lu, Youming
海马体沿其主轴沿着分为背侧区和腹侧区。背侧海马体对于学习和记忆至关重要，然而腹侧海马体的基本功能仍然难以捉摸。在这里，我们基因操纵的兴奋性神经元表达的腹侧海马5-羟色胺受体2c（Htr 2c）的子集。转基因病毒追踪显示，这些Htr 2c细胞与Edinger-Westphal核（EW）中新发现的神经元建立单突触兴奋性连接，该神经元直接支配内侧前额叶皮质。Htr 2c细胞的失活会损害需要注意力的视觉检测任务中的行为表现，而不会影响新物体识别，学习或记忆。这种注意力缺陷被抑制EW细胞重演，并被激活EW细胞或从Htr 2c细胞到EW细胞的突触投射拯救。这项研究揭示了控制注意力的突触通路。
The hippocampus is divided into dorsal and ventral zones along its principal axis. The dorsal hippocampus is critical for learning and memory, yet the basic function of the ventral hippocampus remains elusive. Here we genetically manipulate a subset of excitatory neurons expressing the serotonin receptor 2c (Htr2c) in the ventral hippocampus. Genetically modified virus tracing reveals that these Htr2c cells establish monosynaptic excitatory connections with newly identified neurons in the Edinger-Westphal nucleus (EW), which directly innervate the medial prefrontal cortex. Inactivation of Htr2c cells impairs behavioral performance in a visual-detection task that demands attention, without affecting novel-object recognition, learning, or memory. This attention deficit was recapitulated by inhibition of EW cells and rescued by activation of EW cells or synaptic projections from Htr2c cells onto EW cells. This study uncovers a synaptic pathway for control of attention.