Living in Your Skin: Microbes, Molecules, and Mechanisms.
Living in Your Skin: Microbes, Molecules, and Mechanisms.
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生活在您的皮肤中：微生物，分子和机制。
DOI：
10.1128/iai.00695-20
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发表时间：
2021-03-17
影响因子：
3.1
通讯作者：
Kalan LR
中科院分区：
文献类型：
--
作者：
Swaney MH;Kalan LR
人类皮肤的功能是抵御外部环境的物理、化学和免疫屏障，同时也为其居住的微生物群提供保护，称为皮肤微生物群。微生物区系、宿主皮肤细胞和免疫系统之间的合作负责维持皮肤健康，这种微妙平衡的破坏，如病原体入侵或皮肤屏障的破坏，可能会导致皮肤功能受损。人类皮肤的功能是抵御外部环境的物理、化学和免疫屏障，同时也为其居住的微生物群提供保护，称为皮肤微生物群。微生物区系、宿主皮肤细胞和免疫系统之间的合作负责维持皮肤健康，这种微妙平衡的破坏，如病原体入侵或皮肤屏障的破坏，可能会导致皮肤功能受损。在这篇简短的综述中，我们描述了微生物在不同皮肤状态下的微生物、宿主和免疫相互作用中的作用，包括动态平衡、组织修复和伤口感染。此外，我们强调，越来越多的不同的微生物代谢物和产品已被确定为中介这些相互作用，特别是那些参与宿主-微生物沟通和防御性共生的产品。我们还讨论了许多皮肤共生体所表现出的上下文致病性，并提供了对皮肤微生物组领域未来方向的洞察。
Human skin functions as a physical, chemical, and immune barrier against the external environment while also providing a protective niche for its resident microbiota, known as the skin microbiome. Cooperation between the microbiota, host skin cells, and the immune system is responsible for maintenance of skin health, and a disruption to this delicate balance, such as by pathogen invasion or a breach in the skin barrier, may lead to impaired skin function. Human skin functions as a physical, chemical, and immune barrier against the external environment while also providing a protective niche for its resident microbiota, known as the skin microbiome. Cooperation between the microbiota, host skin cells, and the immune system is responsible for maintenance of skin health, and a disruption to this delicate balance, such as by pathogen invasion or a breach in the skin barrier, may lead to impaired skin function. In this minireview, we describe the role of the microbiome in microbe, host, and immune interactions under distinct skin states, including homeostasis, tissue repair, and wound infection. Furthermore, we highlight the growing number of diverse microbial metabolites and products that have been identified to mediate these interactions, particularly those involved in host-microbe communication and defensive symbiosis. We also address the contextual pathogenicity exhibited by many skin commensals and provide insight into future directions in the skin microbiome field.