Lasso Peptides: Heterologous Production and Potential Medical Application.
Lasso Peptides: Heterologous Production and Potential Medical Application.
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DOI：
10.3389/fbioe.2020.571165
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发表时间：
2020
影响因子：
5.7
通讯作者：
Hua ZC
中科院分区：
文献类型：
--
作者：
Cheng C;Hua ZC
套索肽是在细菌中发现的天然产物。它们属于核糖体合成和翻译后修饰的多肽家族，具有不寻常的套索结构。套索多肽具有显著的热稳定性和蛋白水解性，并具有多种生物活性，如抗菌活性、酶抑制、受体阻断、抗癌和HIV拮抗等。它们对胃肠道疾病、结核病、阿尔茨海默病、心血管疾病、真菌感染和癌症具有潜在的治疗效果。套索多肽具有很高的稳定性，是其他生物活性多肽的良好载体。这些使它们成为制药研究的有吸引力的候选者。本文综述了异源生产套索多肽的方法。此外，还表明了它们的治疗潜力以及它们作为一种有效的表位移植支架的能力。
Lasso peptides are natural products found in bacteria. They belong to a specific family of ribosomally-synthesized and posttranslationally-modified peptides with an unusual lasso structure. Lasso peptides possess remarkable thermal and proteolytic stability and various biological activities, such as antimicrobial activity, enzyme inhibition, receptor blocking, anticancer properties and HIV antagonism. They have promising potential therapeutic effects on gastrointestinal diseases, tuberculosis, Alzheimer’s disease, cardiovascular disease, fungal infections and cancer. Lasso peptides with high stability have been shown to be good carriers for other bioactive peptides. These make them attractive candidates for pharmaceutical research. This review aimed to describe the strategies used for the heterologous production of lasso peptides. Also, it indicated their therapeutical potential and their capacity to use as an efficient scaffold for epitope grafting.