Clinical and Transmission Characteristics of Covid-19-A Retrospective Study of 25 Cases from a Single Thoracic Surgery Department
Clinical and Transmission Characteristics of Covid-19-A Retrospective Study of 25 Cases from a Single Thoracic Surgery Department
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DOI：
10.1007/s11596-020-2176-2
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发表时间：
2020-03-30
影响因子：
2.4
通讯作者：
Fu, Xiang-Ning
中科院分区：
文献类型：
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作者：
Li, Yang-Kai;Peng, Shu;Fu, Xiang-Ning
2019冠状病毒病（Covid-19）的爆发给外科手术患者的管理带来了重大挑战。在本研究中，我们分析了来自单一胸科的25例Covid-19的临床和传播特征，其中包括13例患者和12名医护人员。其中男性13人，女性12人。患者的中位年龄为61岁（范围：51 - 69岁）。卫生保健人员的年龄中位数为35岁（范围：22至51岁）。截至随访日（2020年3月3日），非重症16例（64%），重症9例（36%），死亡5例（20%）。感染病例中经SARS-CoV-2核酸检测确诊19例（76%），临床诊断为疑似病例19例（76%），有阳性暴露史19例（76%）。我们发现COPD与严重程度和死亡显著相关（P=0.040， P=0.038），胸部手术与Covid-19患者死亡显著相关（P=0.039）。在实施隔离和综合防护之前，潜在的“超级传播者”可能是传播源。综上所述，Covid-19与胸外科手术患者预后不良有关，尤其是COPD患者。实施综合防护措施对控制医院感染具有重要意义。
The outbreak of corona virus disease 2019 (Covid-19) imposes a major challenge in managing patients undergoing surgical operation. In this study, we analyzed clinical and transmission features of 25 cases of Covid-19 from a single thoracic department, including 13 patients and 12 health care staff. There were 13 males and 12 females. The median age of the patients was 61 (range: 51 to 69) years. The median age of the health care staff was 35 (range: 22 to 51) years. By the end of follow-up date (Mar. 3, 2020), there were 16 non-severe cases (64%) and 9 severe cases (36%), 5 cases were dead (20%). Nineteen (76%) of the infected cases were confirmed by SARS-CoV-2 nucleic acid test, the rest were clinically diagnosed as suspected Covid-19 cases, and 19 (76%) of the infected cases had positive exposure history. We found that COPD was significantly associated with severity and death (P=0.040, and P=0.038, respectively), and chest operation was significantly associated with death for Covid-19 patients (P=0.039). A potential "super spreader" may be the source of the transmission before the implementation of quarantine and comprehensive protection. It was concluded that Covid-19 is associated with poor prognosis for patients undergoing thoracic operation, especially for those with COPD. Implementation of comprehensive protective measures is important to control nosocomial infection.