Electrical stimulation of the dorsal hippocampus caused a long lasting inhibition of ACTH and adrenocortical responses to photic stimuli in freely moving rats
Electrical stimulation of the dorsal hippocampus caused a long lasting inhibition of ACTH and adrenocortical responses to photic stimuli in freely moving rats
复制标题
DOI：
10.1016/s0006-8993(01)02538-0
复制
发表时间：
2001-08-17
期刊：
影响因子：
2.9
通讯作者：
Weidenfeld, J
中科院分区：
文献类型：
--
作者：
Feldman, S;Weidenfeld, J
在自由活动的雄性大鼠中研究了海马单列电刺激对 ACTH 和皮质酮 (CS) 对随后光刺激反应的影响。与假刺激动物相比，海马刺激抑制了应激并导致血清 CS 水平升高长达 150 小时。这种效应在刺激后 300 小时不存在。这种海马对肾上腺皮质反应的持续抑制作用以前没有报道过，但被背穹窿部分消除了。目前的数据表明，背侧海马刺激对神经刺激后的垂体肾上腺皮质分泌具有长期持续的抑制作用，这部分是由背侧穹窿介导的。 (C) 2001 Elsevier Science B.V. 保留所有权利。
The effect of a sin-le train of electrical hippocampal stimulation on ACTH and corticosterone (CS) responses to subsequent photic stimulation was studied in freely moving male rats. The hippocampal stimulation inhibited the stress and induced a rise in serum CS levels up to 150 h when compared to sham stimulated animals. This effect did not exist at 300 h following stimulation. This sustained hippocampal inhibitory effect on the adrenocortical response, which was not reported previously, was partially abolished by section of the dorsal fornix. The present data demonstrate that dorsal hippocampal stimulation has a long lasting inhibitory effect on pituitary adrenocortical secretion following neural stimuli and this is partially mediated by the dorsal fornix. (C) 2001 Elsevier Science B.V. All rights reserved.