Localization of alpha/beta and gamma/delta T lymphocytes in Cryptosporidium parvum-infected tissues in naive and immune calves
Localization of alpha/beta and gamma/delta T lymphocytes in Cryptosporidium parvum-infected tissues in naive and immune calves
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DOI：
10.1128/iai.65.6.2428-2433.1997
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发表时间：
1997-06-01
影响因子：
3.1
通讯作者：
Jutila, MA
中科院分区：
文献类型：
--
作者：
Abrahamsen, MS;Lancto, CA;Jutila, MA
微小隐孢子虫感染后寄主在肠道绒毛内的T淋巴细胞群体的性质是以牛隐孢子虫病模型为特征的。在幼稚动物中，感染微小隐孢子虫后，回肠绒毛中的α/βT细胞数量显著增加，其中CD_4(+)和CD_8(+)均为150%，CD_8(+)为60%，γ/βT细胞(70%)显著增加。免疫动物中，宿主T淋巴细胞对攻击性感染的反应仅限于α/βT细胞，回肠Peyer‘s区的CD_4(+)T细胞数量显著增加；攻击性感染后，肠绒毛内CD8(+)T细胞的数量增加，且CD8(+)T细胞与肠绒毛上皮细胞关系密切。CD8(+)T细胞的聚集与寄生虫发育的正常部位之间的精确相关性表明CD8(+)T细胞在免疫动物中起着重要作用。
The nature of the host's T-lymphocyte population within the intestinal villi following Cryptosporidium parvum infection was characterized with a bovine model of cryptosporidiosis. In naive animals, infection with C. parvum resulted in substantial increases in the numbers of alpha/beta T cells, both CD4(+) (150%) and CD8(+) (60%), and of gamma/delta T cells (70%) present within the intestinal villi of the infected ileum, In immune animals, the host T-lymphocyte response to a challenge infection with C. parvum was restricted to alpha/beta T cells, The number of CD4(+) T cells within the Peyer's patch of the ileum increased dramatically; however, there a-as little change in the number or localization of CD4(+) T cells within the intestinal villi, In contrast, the number of CD8(+) T cells within the intestinal villi increased following a challenge infection, In addition, the CD8(+) T cells were found to he intimately associated with the epithelial cells of the intestinal villi. The precise correlation between the accumulation of CD8(+) T cells and the normal site of parasite development suggests an important role for CD8(+) T cells in the immune animal.