Neural correlates of cognitive decline in ALS: an fNIRS study of the prefrontal cortex.
Neural correlates of cognitive decline in ALS: an fNIRS study of the prefrontal cortex.
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ALS 认知能力下降的神经相关性：前额皮质的 fNIRS 研究。
DOI：
10.1080/17588928.2013.797889
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发表时间：
2013
影响因子：
2
通讯作者：
Murman,DanielL
中科院分区：
文献类型：
--
作者：
Kuruvilla,MiliS;Green,JordanR;Ayaz,Hasan;Murman,DanielL
功能性近红外光谱（fNIRS）是一种临床上可行的功能性神经成像模式，用于检测由于影响认知的神经退行性疾病引起的早期皮质变化。这项初步研究的目的是测试由于肌萎缩侧索硬化症（ALS）引起的认知障碍患者的前额叶活动减少。参与者被要求在fNIRS记录期间完成两项复杂性不断增加的N-back工作记忆任务。五名ALS参与者和年龄和性别匹配的健康参与者分别组成实验组和对照组。与对照组相比，在ALS组中观察到左半球和右半球的前额叶氧合水平显著降低。尽管工作记忆任务的行为表现完好，但前额叶激活减少可能表明受影响个体的早期神经解剖学，神经生理学和/或代偿机制。fNIRS衍生的氧合测量显示出作为识别ALS所致早期神经心理障碍的敏感神经标志物的前景。
Functional near infrared spectroscopy (fNIRS) is a clinically feasible functional neuroimaging modality for detecting early cortical changes due to neurodegenerative diseases that affect cognition. The objective of this preliminary investigation was to test for reduced prefrontal activity in persons with cognitive impairments due to amyotrophic lateral sclerosis (ALS). Participants were required to complete two N-back working memory tasks of increasing complexity during fNIRS recordings. Five participants with ALS and age- and gender-matched healthy participants comprised the experimental and control groups, respectively. Significant reductions in prefrontal oxygenation levels were observed for the left and right hemispheres in the ALS group compared to the control group. Reduced prefrontal activation despite intact behavioral performance for a working memory task may suggest early neuroanatomical, neurophysiological and/or compensatory mechanisms in affected individuals. The fNIRS-derived oxygenation measure shows promise as a sensitive neural marker to identify early neuropsychological impairments due to ALS.