[Role of vimentin in tumor metastasis and drug research].
[Role of vimentin in tumor metastasis and drug research].
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发表时间：
2010-12
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通讯作者：
Yan Pan;Jing Han;Ye Zhang;Xue-jun Li
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作者：
Yan Pan;Jing Han;Ye Zhang;Xue-jun Li
波形蛋白是间充质细胞的主要中间丝蛋白。最近的研究表明，波形蛋白与肿瘤的发生和转移密切相关。波形蛋白可以调节细胞骨架蛋白与细胞黏附分子的相互作用，从而参与肿瘤细胞、肿瘤相关内皮细胞和巨噬细胞的黏附、迁移、侵袭和细胞信号转导。它在聚合体和解聚体之间的高度动态平衡及其复杂的磷酸化可能是肿瘤转移和细胞间相互作用的调节机制。波形蛋白很可能成为抗转移治疗和研究的新靶点。
Vimentin is the major intermediate filament (IF) protein of mesenchymal cells. Recent studies have shown that vimentin was closely linked with tumorigenesis and metastasis. Vimentin could regulate the interaction between cytoskeletal proteins with cell adhesion molecules and thereby participate in cell adhesion, migration, invasion and cell signal transduction in tumor cells, tumor-associated endothelial cells and macrophages. Its highly dynamic balances between polymer and depolymerization and its complex phosphorylation may serve as the regulation mechanisms for tumor metastasis and cell-cell interactions. Vimentin is likely to be a new target for anti-metastatic therapies and research.