CMV induces HERV-K and HERV-W expression in kidney transplant recipients
CMV induces HERV-K and HERV-W expression in kidney transplant recipients
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DOI：
10.1016/j.jcv.2015.04.018
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发表时间：
2015-07-01
影响因子：
8.8
通讯作者：
Ravanini, Paolo
中科院分区：
文献类型：
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作者：
Bergallo, Massimiliano;Galliano, Ilaria;Ravanini, Paolo
背景：人类内源性逆转录病毒（HERVs）约占人类基因组的8%。HERV转录的诱导在某些情况下是可能的，并且可能在某些病理条件下具有可能的作用。目的：本研究的目的是评估肾移植受者中HERV-K和-W pol基因的表达，并调查这些患者中HERV基因表达和CMV感染之间的可能关系。采用相对定量Real-Time PCR方法检测33例肾移植患者和20例健康献血员的HERV-K和-W pol基因RNA表达。我们证明，HERVs pol基因表达水平在肾移植受者中高于健康受试者。此外，HERV-K和-W pol基因的表达显着较高的组中的肾移植受者与高CMV病毒载量比组中没有或中等CMV病毒load.Conclusion：我们的数据表明，CMV可能会促进体内HERV激活。由爱思唯尔公司出版
Background: Human endogenous retrovirus (HERVs) constitute approximately 8% of the human genome. Induction of HERV transcription is possible under certain circumstances, and may have a possible role in some pathological conditions.Objectives: The aim of this study was to evaluate HERV-K and -W pol gene expression in kidney transplant recipients and to investigate the possible relationship between HERVs gene expression and CMV infection in these patients.Study design: Thirty-three samples of kidney transplant patients and twenty healthy blood donors were used to analyze, HERV-K and -W pol gene RNA expression by relative quantitative relative Real-Time PCR.Result: We demonstrated that HERVs pol gene expression levels were higher in kidney transplant recipients than in healthy subjects. Moreover, HERV-K and -W pol gene expression was significantly higher in the group of kidney transplant recipients with high CMV viral load than in the groups with no or moderate CMV viral load.Conclusion: Our data suggest that CMV may facilitate in vivo HERV activation. Published by Elsevier B.V.