Late-Stage Fluorination: Fancy Novelty or Useful Tool?
Late-Stage Fluorination: Fancy Novelty or Useful Tool?
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DOI：
10.1002/anie.201410288
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发表时间：
2015-03-09
影响因子：
16.6
通讯作者：
Ritter, Tobias
中科院分区：
文献类型：
--
作者：
Neumann, Constanze N.;Ritter, Tobias
迷人的氟：本文考察了最近后期氟化反应的激增，并概述了需要克服的挑战，以增加现代氟化方法对复杂有机氟化合物合成的影响。它概述了如何提高对氟的键相互作用的理解可能导致一类新的轻度氟化试剂和一系列官能团耐受反应。
Charming fluorine: This Essay examines the recent surge in late-stage fluorination reactions and outlines challenges that need to be overcome to increase the impact of modern fluorination methods on the synthesis of complex organofluorine compounds. It is outlined how an improved understanding of the bonding interactions of fluoride could lead to a new class of mild fluorinating reagents and a range of functional-group-tolerant reactions.