Phosphonium salt-catalysed synthesis of nitriles from in situ activated oximes
Phosphonium salt-catalysed synthesis of nitriles from in situ activated oximes
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DOI：
10.1016/j.tet.2012.01.067
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发表时间：
2012-04-01
期刊：
影响因子：
2.1
通讯作者：
Lewis, William
中科院分区：
文献类型：
--
作者：
Denton, Ross M.;An, Jie;Lewis, William
本文报道了一种在室温下用草酰氯（1.2equiv）和5mol%的三苯基氧化膦将芳香族和脂肪族醛肟转化为腈的无金属催化方法。在从肟到腈的许多潜在途径中，涉及氯鏻盐催化原位形成的肟氯代甲酸酯的分解的歧管被证明是有效的。(C)2012爱思唯尔有限公司出版
A metal-free catalytic method for the conversion of aromatic and aliphatic aldoximes to nitriles at room temperature using oxalyl chloride (1.2 equiv) in combination with 5 mol % of triphenylphosphine oxide is reported. Of the many potential pathways leading from oxime to nitrile a manifold involving chlorophosphonium salt-catalysed decomposition of oxime chlorooxalates formed in situ is shown to be operative. (C) 2012 Published by Elsevier Ltd.