Self-assembled supramolecular hydrogels formed by biodegradable PEO-PHB-PEO triblock copolymers and α-cyclodextrin for controlled drug delivery
Self-assembled supramolecular hydrogels formed by biodegradable PEO-PHB-PEO triblock copolymers and α-cyclodextrin for controlled drug delivery
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DOI：
10.1016/j.biomaterials.2006.03.025
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发表时间：
2006-08-01
期刊：
影响因子：
14
通讯作者：
Leong, Kam W.
中科院分区：
文献类型：
--
作者：
Li, Jun;Li, Xu;Leong, Kam W.
研究了α-环糊精与可生物降解的聚环氧乙烷(oxide)-poly[(R)-3-hydroxybutyrate]-poly(ethylene)三嵌段共聚物自组装超分子水凝胶的材料设计。聚氧化乙烯链段与α-环糊精的络合作用和PHB嵌段之间的疏水相互作用形成了具有较强大分子网络的超分子水凝胶。异硫氰酸荧光素标记的葡聚糖(葡聚糖-FITC)模型药物的体外释放动力学研究表明，该水凝胶适合大分子药物的较长时间的缓控释，这是许多简单的三嵌段共聚物水凝胶体系所不能实现的。该水凝胶具有触变性和可逆性，可作为一种很有前途的注射给药系统。(C)2006爱思唯尔有限公司。保留所有权利。
A materials design of a new supramolecular hydrogel self-assembled between alpha-cyclodextrin and a biodegradable poly(ethylene oxide)-poly[(R)-3-hydroxybutyrate]-poly(ethylene oxide) (PEO-PHB-PEO) triblock copolymer was demonstrated. The cooperation effect of complexation of PEO segments with a-cyclodextrin and the hydrophobic interaction between PHB blocks resulted in the formation of the supramolecular hydrogel with a strong macromolecular network. The in vitro release kinetics studies of fluorescein isothiocyanate labeled dextran (dextran-FITC) model drug from the hydrogel showed that the hydrogel was suitable for relatively long-term sustained controlled release of macromolecular drugs, which many simple triblock copolymer hydrogel systems could not achieve. The hydrogel was found to be thixotropic and reversible, and can be applied as a promising injectable drug delivery system. (c) 2006 Elsevier Ltd. All rights reserved.