In vitro bioactive characteristics of borate-based glasses with controllable degradation behavior
In vitro bioactive characteristics of borate-based glasses with controllable degradation behavior
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DOI：
10.1111/j.1551-2916.2006.01358.x
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发表时间：
2007-01-01
影响因子：
3.9
通讯作者：
Day, Delbert E.
中科院分区：
文献类型：
--
作者：
Yao, Aihua;Wang, Deping;Day, Delbert E.
硅酸盐基生物活性玻璃在体内植入后不完全转化为磷酸钙材料，这严重限制了其生物医学应用。本研究开发了具有可控降解行为的新型硼酸盐玻璃，并对其体外生物活性进行了研究。当在37 ℃下浸入0.02M K2 HPO 4溶液中时，这些玻璃发生反应，在其表面形成碳酸盐取代的羟基磷灰石（c-HA），表明其生物活性潜力。通过调节玻璃组合物中的B2 O3/SiO2比率来控制向c-HA的转化率。结果表明，硼酸盐基生物活性玻璃作为骨组织工程支架材料具有潜在的应用前景。
Silicate-based bioactive glasses undergo incomplete conversion to a calcium phosphate material after in vivo implantation, which severely limits their biomedical application. In this communication, novel borate-based glasses with controllable degradation behavior were developed and their bioactive potential was investigated in vitro. When immersed in a 0.02M K2HPO4 solution at 37 degrees C, these glasses reacted to form a carbonate-substituted hydroxyapatite (c-HA) on their surfaces, indicating their bioactive potential. The conversion rate to c-HA was controlled by adjusting the B2O3/SiO2 ratio in the glass composition. The results indicate the potential application of the borate-based bioactive glass as scaffold materials for bone tissue engineering.