Combining Whole-Brain Voxel-Wise Analysis with In Vivo Tractography of Diffusion Behavior after Sports-Related Concussion in Adolescents: A Preliminary Report
Combining Whole-Brain Voxel-Wise Analysis with In Vivo Tractography of Diffusion Behavior after Sports-Related Concussion in Adolescents: A Preliminary Report
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DOI：
10.1089/neu.2012.2818
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发表时间：
2013-07-01
影响因子：
4.2
通讯作者：
Virji-Babul, Naznin
中科院分区：
文献类型：
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作者：
Borich, Michael;Makan, Nadia;Virji-Babul, Naznin
我们之前已经证明，青少年运动相关的脑震荡与全脑白质通路特性的变化有关。在这里，我们评估了这些途径中的局部变化。12名临床诊断为亚急性脑震荡的青少年和10名年龄、性别和身体活动相匹配的健康青少年完成了磁共振成像扫描。采用基于体素的通道空间统计和通道成像来评估两组之间基于扩散的白质通路微观结构特性测量（分数各向异性、平均扩散系数、径向扩散系数和轴向扩散系数）的局部变化。基于神经束的空间统计显示，脑震荡组在多个脑簇区域的分数各向异性值更高，主要是在额叶白质区域，包括双侧前辐射冠。利用这些扩散特征改变的区域进行种子纤维束造影，在脑震荡组中检测到通过这些区域的束轴向扩散率显著降低（p = 0.04）。在相同的重建束内，也观察到脑震荡组的平均扩散率和径向扩散率降低的趋势。这些束内的扩散行为与脑震荡状态评估显著相关（运动脑震荡评估工具2）。重建小束内的各向异性分数在两组间无显著差异。这些结果表明，青少年亚急性脑震荡与局部白质组织和沿重建纤维通路的扩散特性改变有关。将体素分析与纤维束造影相结合，为评估和识别脑震荡后白质纤维完整性的细微变化提供了另一种客观的方法。
We have previously shown that sports-related concussion in adolescents is associated with changes in whole-brain properties of white-matter pathways. Here, we assess local changes within these pathways. Twelve adolescents with a clinical diagnosis of subacute concussion and 10 healthy adolescents matched for age, gender, and physical activity completed magnetic resonance imaging scanning. Voxel-wise tract-based spatial statistics and tractography were performed to assess local changes in diffusion-based measures of microstructural properties of white-matter pathways (fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity) between the two groups. Fractional anisotropy values were higher for the concussed group in multiple cluster regions using tract-based spatial statistics, primarily in frontal white-matter regions, including the anterior corona radiata bilaterally. Using these regions of altered diffusion characteristics to seed fiber tractography, significantly reduced axial diffusivity in tracts passing through these areas were detected in the concussed group (p = 0.04). A trend toward reduced mean and radial diffusivity in the concussed group was also observed within the same reconstructed tracts. Diffusion behavior within these tracts was significantly correlated with an assessment of concussion status (Sports Concussion Assessment Tool 2). Fractional anisotropy within the reconstructed tracts was not significantly different between the two groups. These results suggest that subacute concussion in adolescents is associated with altered diffusion properties within regional white-matter tissue and along reconstructed fiber pathways. Combining voxel-wise analysis with fiber tractography provides an alternative objective approach to evaluate and identify subtle changes in white-matter fiber integrity after concussion.