The association between trait anger and incident stroke risk - The Atherosclerosis Risk in Communities (ARIC) study
The association between trait anger and incident stroke risk - The Atherosclerosis Risk in Communities (ARIC) study
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DOI：
10.1161/hs0102.101625
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发表时间：
2002-01-01
期刊：
影响因子：
8.3
通讯作者：
Tyroler, HA
中科院分区：
文献类型：
--
作者：
Williams, JE;Nieto, FJ;Tyroler, HA
背景和目的-本研究探讨了特质愤怒和事件中风风险之间的关系，参与者没有中风的历史，在第一次随访检查的动脉粥样硬化风险在社区（ARIC）study. Methods-该研究样本包括13 851名黑人和白色男性和女性，年龄在48至67岁，谁完成了Spielberger特质愤怒量表。中位随访时间为77.3 months.Results-In整个队列，考克斯比例风险回归分析显示，高特质愤怒的个体中风的风险适度增加，但在多变量调整后，这种关联并没有保持统计学显著性。小于或等于60岁的参与者报告有高特质愤怒，出血性和缺血性卒中合并（任何）的风险高出（95% CI，1.65至4.80）倍，（95%可信区间，1.64至5.22）倍的缺血性中风的风险比那些报告有低特质愤怒的同行（根据性别和人种/种族调整的风险率比）。类似地，在HDL胆固醇水平>47的参与者中，报告具有高特质愤怒的人发生任何中风的风险是2.86倍（95%CI，1.56至5.25），而单独发生缺血性中风的风险是2.98倍（95%CI，1.58至5.61）（根据年龄，性别和种族/民族调整的风险率比）。这些协会仍然很强，统计学显着进一步调整后，为几个既定的生物和社会人口风险因素中风和老年参与者和低HDL胆固醇values. Conclusions特质愤怒是不存在的风险增加事件中风在ARIC研究中年轻的参与者和高HDL胆固醇水平。
Background and Purpose-This study examined the relation between trait anger and incident stroke risk among participants without a history of stroke at the first follow-up examination of the Atherosclerosis Risk in Communities (ARIC) study.Methods-The study sample included 13 851 black and white men and women, aged 48 to 67 years, who completed the Spielberger Trait Anger Scale. Median follow-up time was 77.3 months.Results-In the full cohort, Cox proportional hazards regression analyses showed a modest increase in the risk for stroke among individuals with high trait anger, though the association did not remain statistically significant after multivariate adjustment. Participants less than or equal to60 years of age who reported having high trait anger had a 2.82 (95% CI, 1.65 to 4.80) times greater risk for hemorrhagic and ischemic strokes combined (any) and a 2.93 (95% CI, 1.64 to 5.22) times greater risk for ischemic strokes alone than their counterparts who reported having low trait anger (hazard rate ratios adjusted for sex and race/ethnicity). Similarly, among participants with HDL cholesterol levels >47, the risk for any stroke was 2.86 (95% CI, 1.56 to 5.25) times greater for those who reported having high trait anger, whereas the risk for ischemic strokes alone was 2.98 (95% CI, 1.58 to 5.61) times greater (hazard rate ratios adjusted for age, sex, and race/ethnicity). These associations remained strong and statistically significant after further adjustment for several established biological and sociodemographic risk factors for stroke and were absent among older participants and those with lower HDL cholesterol values.Conclusions-Trait anger was associated with an increased risk for incident stroke in the ARIC study among younger participants and those with higher HDL cholesterol levels.