High Density Lipoprotein and it's Dysfunction.
High Density Lipoprotein and it's Dysfunction.
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DOI：
10.2174/1874091x01206010078
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Aydin O
中科院分区：
文献类型：
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作者：
Eren E;Yilmaz N;Aydin O
血浆高密度脂蛋白胆固醇（HDL-C）水平不能预测高密度脂蛋白（HDL）的功能和组成。传统上，保持低密度脂蛋白胆固醇（LDL-C）水平和高密度脂蛋白胆固醇（HDL-C）水平一直是患者预防可导致冠状血管疾病（CVD）的动脉粥样硬化的目标。人们只考虑胆固醇测试中的HDL，而不考虑它的功能。 高达65%的心血管死亡无法通过假定的LDL-C降低药物预防。这很好地解释了对HDL增加策略的强烈兴趣。然而，最近的研究质疑使用药物增加HDL水平的好处。虽然提高HDL在理论上是一个有吸引力的目标，但最佳方法仍不确定。人们的注意力已经转向HDL-C的质量，而不是数量。HDL升高的替代方案涉及增强HDL功能的策略。 这种情况为临床化学家提供了一个机会，使他们能够带头开发和验证这种生物标志物。HDL最为人所知的功能是促进细胞胆固醇从外周细胞流出并将胆固醇递送至肝脏排泄的能力，从而在胆固醇逆向转运（RCT）中发挥关键作用。HDL的抗炎和抗氧化活性是近年来备受关注的功能。HDL的高抗氧化和抗炎活性与保护CVD有关。本文综述了目前关于HDL功能测定及其与心血管疾病关系的知识现状。HDL作为治疗靶点是一个新的前沿领域，具有巨大的积极公共卫生影响潜力。
Plasma high-density lipoprotein cholesterol(HDL-C) levels do not predict functionality and composition of high-density lipoprotein(HDL). Traditionally, keeping levels of low-density lipoprotein cholesterol(LDL-C) down and HDL-C up have been the goal of patients to prevent atherosclerosis that can lead to coronary vascular disease(CVD). People think about the HDL present in their cholesterol test, but not about its functional capability. Up to 65% of cardiovascular death cannot be prevented by putative LDL-C lowering agents. It well explains the strong interest in HDL increasing strategies. However, recent studies have questioned the good in using drugs to increase level of HDL. While raising HDL is a theoretically attractive target, the optimal approach remains uncertain. The attention has turned to the quality, rather than the quantity, of HDL-C. An alternative to elevations in HDL involves strategies to enhance HDL functionality. The situation poses an opportunity for clinical chemists to take the lead in the development and validation of such biomarkers. The best known function of HDL is the capacity to promote cellular cholesterol efflux from peripheral cells and deliver cholesterol to the liver for excretion, thereby playing a key role in reverse cholesterol transport (RCT). The functions of HDL that have recently attracted attention include anti-inflammatory and anti-oxidant activities. High antioxidant and anti-inflammatory activities of HDL are associated with protection from CVD. This review addresses the current state of knowledge regarding assays of HDL functions and their relationship to CVD. HDL as a therapeutic target is the new frontier with huge potential for positive public health implications.