DARC: a new method for detecting progressive neuronal death
DARC: a new method for detecting progressive neuronal death
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DOI：
10.1038/sj.eye.6702881
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发表时间：
2007-12-01
期刊：
影响因子：
3.9
通讯作者：
Cordeiro, M. F.
中科院分区：
文献类型：
--
作者：
Cordeiro, M. F.
视野评估目前被用作评估青光眼疾病进展的金标准，但这种方法考虑了已经发生的不可逆转的损害。如果可以检测到视网膜神经节细胞（RGC）凋亡，则可以防止视力丧失，并且可以在更早的阶段采取行动，以避免神经元的继发性变性和疾病的进展。视网膜细胞凋亡检测 (DARC) 是一种使用先进光学技术对体内 RGC 随时间变化的过程进行成像和跟踪的方法。它有可能帮助阐明青光眼 RGC 变性和视力丧失发展中涉及的细胞机制。
Visual field evaluations are currently used as the gold standard in assessing disease progression in glaucoma, but this method considers damage that has irreversibly occurred. If retinal ganglion cell (RGC) apoptosis can be detected, it may be possible to prevent loss of vision, and also to act at a much earlier stage to avoid the secondary degeneration of neurons and progression of the disease. Detection of apoptosing retinal cells (DARC) is a method that uses advanced optical techniques to image and track the process of RGCs in vivo over time. It has the potential to help elucidate the cellular mechanisms involved in the development of RGC degeneration and vision loss in glaucoma.