Photoactivated Nanohybrid for Dual-Nuclei MR/US/PA Multimodal-Guided Photothermal Therapy.
Photoactivated Nanohybrid for Dual-Nuclei MR/US/PA Multimodal-Guided Photothermal Therapy.
复制标题
DOI：
10.1021/acs.bioconjchem.2c00343
复制
发表时间：
2022-09
影响因子：
4.7
通讯作者：
Shizhen Chen;Maosong Qiu;Ruifang Wang;Lei Zhang;Cong-Na Li;Chaohui Ye;Xin Zhou
中科院分区：
文献类型：
--
作者：
Shizhen Chen;Maosong Qiu;Ruifang Wang;Lei Zhang;Cong-Na Li;Chaohui Ye;Xin Zhou
纳米复合物因其良好的生物相容性、生物降解性和靶向性，在肺癌的诊断和化疗中得到了广泛的应用。然而，它们中的大多数遭受有限的成像信息，低肿瘤与背景比，和多药耐药，限制了它们潜在的临床应用。本文中，我们通过组装聚吡咯@牛血清白蛋白（PPy@BSA）包封全氟戊烷（PFP）/129 NH 4来设计光响应纳米杂化物，用于肺癌的选择性磁共振（MR）/超声（US）/光声（PA）三模态成像和光热治疗，克服了单一成像模式和化疗的这些缺点。该纳米混合物在肺癌检测中表现出优越的上级US、PA和MR多模态成像性能。纳米混合物对近红外光（NIR）的高灵敏度导致在低强度激光状态下温度迅速升高，这引发了液体PFP向气体的相变。肿瘤内部的超声信号，最初几乎为零，急剧增加。除此之外，它还导致了激光照射期间19 F/129 F Hyper-CEST（化学交换饱和转移）MRI的完全抑制，可以精确定位肺癌。纳米复合物的体外和体内结果显示出对肺癌的成功治疗效果。在影像学结果的指导下，光热疗法（PTT）治疗肺癌取得了良好的效果。我们期望这种纳米杂交和光敏行为将有助于作为通过三模态成像方法在早期阶段破译肺癌的基本工具。
Nanohybrids have gained immense popularity for the diagnosis and chemotherapy of lung cancer for their excellent biocompatibility, biodegradability, and targeting ability. However, most of them suffer from limited imaging information, low tumor-to-background ratios, and multidrug resistance, limiting their potential clinical application. Herein, we engineered a photoresponsive nanohybrid by assembling polypyrrole@bovine serum albumin (PPy@BSA) encapsulating perfluoropentane (PFP)/129Xe for selective magnetic resonance (MR)/ultrasonic (US)/photoacoustic (PA) trimodal imaging and photothermal therapy of lung cancer, overcoming these drawbacks of single imaging modality and chemotherapy. The nanohybrid exhibited superior US, PA, and MR multimodal imaging performance for lung cancer detection. The high sensitivity of the nanohybrid to near-infrared light (NIR) resulted in a rapid increase in temperature in a low-intensity laser state, which initiated the phase transition of liquid PFP into the gas. The ultrasound signal inside the tumor, which is almost zero initially, is dramatically increased. Beyond this, it led to the complete depression of 19F/129Xe Hyper-CEST (chemical exchange saturation transfer) MRI during laser irradiation, which can precisely locate lung cancer. In vitro and in vivo results of the nanohybrid exhibited a successful therapeutic effect on lung cancer. Under the guidance of imaging results, a sound effect of photothermal therapy (PTT) for lung cancer was achieved. We expect this nanohybrid and photosensitive behavior will be helpful as fundamental tools to decipher lung cancer in an earlier stage through trimodality imaging methods.