Effect of skin temperature on selective vascular injury caused by pulsed laser irradiation.
Effect of skin temperature on selective vascular injury caused by pulsed laser irradiation.
复制标题
皮肤温度对脉冲激光照射引起的选择性血管损伤的影响。
DOI：
10.1111/1523-1747.ep12277154
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Parrish,JA
中科院分区：
文献类型：
--
作者：
Tan,OT;Kerschmann,R;Parrish,JA
研究了皮肤温度对脉冲激光致血管特异性损伤的影响。10名健康的人类志愿者暴露在波长为577nm的染料激光发出的1.5微秒脉冲下。与常温条件下（33°C皮肤温度）相比，当皮肤冷却至20°C或加热至40°C时，产生肉眼可见的紫癜所需的激光能量显著增加（p < 0.01）。组织学上，在所有三种皮肤温度下，激光诱导的损伤都局限于血管。在紫癜阈值剂量下，在20℃有血管内凝集而无红细胞外渗，而在33℃和40℃有红细胞外渗。
The effect of skin temperature on vascular-specific injury caused by pulsed laser irradiation was examined. Ten healthy human volunteers were exposed to 1.5 microsecond pulses from a dye laser tuned to 577 nm. Compared to normothermic conditions (33°C skin temperature) significantly more laser energy (p < 0.01) was required to produce grossly visible purpura when the skin was cooled to 20°C or heated to 40°C. Histologically, laser-induced damage was confined to blood vessels at all three skin temperatures studied. At purpura threshold dose, there was intravascular agglutination without extravasation of red blood cells at 20°C whereas at 33° and 40°C there was extravasation of red blood cells.