Formulation of calcium phosphates/poly (d,l-lactide) blends containing gentamicin for bone implantation
Formulation of calcium phosphates/poly (d,l-lactide) blends containing gentamicin for bone implantation
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DOI：
10.1016/s0168-3659(00)00251-0
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发表时间：
2000-07-31
影响因子：
10.8
通讯作者：
Évora, C
中科院分区：
文献类型：
--
作者：
Soriano, I;Évora, C
描述了用于预防或治疗骨髓炎的植入物，由含有抗生素庆大霉素的磷酸盐/聚（d，l-丙交酯）混合物组成。在433 MPa和693 MPa的压缩压力下，制备了含有3%硫酸庆大霉素（GS）的7个种植体配方。共混物含有25%羟基磷灰石（HAP）、75%磷酸三钙（TCP）和20% dl-PLA（重量平均分子量，M-w: 30 kD）的磷酸盐。为了延长GS释放，植入物涂有PLGA （M-w:100 kD）或dl-PLA （M-w: 200 kD）。从这些装置中释放GS的各种持续时间被证明是可行的。植入物包被dl-PLA (M-w: 200 kD)，释放时间超过10周，大大超过商业配方的性能。(C) 2000 Elsevier Science S.V.版权所有
Implants to prevent or treat osteomyelitis are described, composed of phosphate/poly(d,l-lactide) blends containing the antibiotic gentamicin. Seven formulations of implants containing 3% gentamicin sulfate (GS) were prepared at 433 MPa and 693 MPa of compression pressure. The blends contained phosphates (25% hydroxyapatite (HAP), 75% tricalcium phosphate (TCP)) and 20% dl-PLA (weight average molecular weight, M-w: 30 kD). To prolong GS release, implants were coated with PLGA (M-w:100 kD) or dl-PLA (M-w: 200 kD). Various durations of GS release from these devices were demonstrated as feasible. Release times of more than 10 weeks were attained with implants coated with dl-PLA (M-w: 200 kD), greatly exceeding the performance of the commercial formulation. (C) 2000 Elsevier Science S.V. All rights reserved.