Thalamic reductions in children with chromosome 22qll.2 deletion syndrome
Thalamic reductions in children with chromosome 22qll.2 deletion syndrome
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DOI：
10.1097/01.wnr.0000129855.50780.85
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发表时间：
2004-06-28
期刊：
影响因子：
1.7
通讯作者：
Simon, TJ
中科院分区：
文献类型：
--
作者：
Bish, JP;Nguyen, V;Simon, TJ
患有染色体22 q11.2缺失综合征（22 q）的儿童患有身体和行为功能障碍，包括神经解剖异常、视觉空间处理缺陷以及精神病理学风险增加。已报告总脑体积、顶叶体积和小脑体积减少，脑室扩大和基底节体积增加。由于以前的文献已经将丘脑枕核与视觉空间处理联系起来，我们比较了22 q儿童的丘脑体积与典型发育对照组。与正常发育的儿童相比，22 q儿童的丘脑明显减少，特别是在丘脑的后部，包括枕核。这些结果提供了第一个证据，证明后丘脑减少和该组中表现出的特征性视觉空间缺陷之间的潜在关系。
Children with chromosome 22q11.2 deletion syndrome (22q) suffer from physical and behavioral dysfunctions, including neuroanatomical anomalies, visuo-spatial processing deficits, and increased risk for psychopathology. Reduced total brain volume, parietal lobe volume, and cerebellar volumes, enlarged ventricles, and increased basal ganglia volumes have been reported. Since previous literature has related the pulvinar nucleus of the thalamus to visuo-spatial processing, we compared the thalamic volume in children with 22q to typically developing controls. Children with 22q showed a significant reduction of the thalamus compared with normally developing children, specifically in the posterior portion of the thalamus, including the pulvinar nucleus. These results provide the first evidence for a potential relationship between posterior thalamic reductions and the characteristic visuo-spatial deficits demonstrated in this group.