Experimental animal models of intracerebral hemorrhage
Experimental animal models of intracerebral hemorrhage
复制标题
DOI：
10.1016/s1042-3680(02)00006-2
复制
发表时间：
2002-07-01
影响因子：
2.6
通讯作者：
Wagner, KR
中科院分区：
文献类型：
--
作者：
Andaluz, N;Zuccarello, M;Wagner, KR
实验性脑出血（ICH）已在几种模型和物种中进行了研究，包括大鼠、兔、猫、狗和灵长类动物。本文讨论了通过将自体血液注入特定脑区产生血肿的模型。这些模型对ICH诱导损伤的认识做出了重大贡献，包括质量效应和颅内压升高的作用、血流和代谢的改变以及特定血液成分对脑水肿形成和血脑屏障（131313）破坏的影响。这些模型还提供了生物化学和分子事件的细节，并且它们能够测试潜在的治疗方法，包括药理学和外科手术。本文首先描述了脑出血的动物模型的病理反应，然后讨论了更详细的研究结果，已获得与个别物种和模型。
Experimental intracerebral hemorrhage (ICH) has been studied in several models and species, including the rat, rabbit, cat, dog, and primate. This article discusses models developed in which hematomas are Produced by infusing autologous blood into specific brain regions. These models have contributed significantly to the knowledge of ICH-induced injury, including the roles of mass effect and elevated intracranial pressure, alterations in blood flow and metabolism, and the impact of specific blood components on brain edema formation and blood-brain barrier (131313) disruption. These models also provide details of biochemical and molecular events, and they enable testing of potential therapies, both pharmacologic and surgical. This article first describes the brain pathologic responses to ICH in animal models, then discusses in more detail findings that have been obtained with individual species and models.