Functional rearrangement of language areas in patients with tumors of the central nervous system using functional magnetic resonance imaging
Functional rearrangement of language areas in patients with tumors of the central nervous system using functional magnetic resonance imaging
复制标题
使用功能磁共振成像研究中枢神经系统肿瘤患者语言区的功能重排
作者：
K. Kośla;Lucjan Pfajfer;B. Bryszewski;D. Jaskólski;L. Stefanczyk;A. Majos
摘要背景：本研究的目的是使用功能性磁共振成像（fMRI）来确定位于语言中心附近的肿瘤患者的语言区域的重组。材料/方法：在手术治疗11名右利手患者之前进行了fMRI，这些患者的肿瘤位于左半球的Broca或Wernicke区域附近。分析包括四个感兴趣区域（ROI）的活动记录：布罗卡区和韦尼克区，以及它们在右半球的解剖同源物。对于每一个病人的区域偏侧化指数分别计算布罗卡面积与其右半球同系物和韦尼克面积与其右半球同系物。结果与肿瘤的组织病理学类型和大小有关。结果如下：我们的功能磁共振成像检查显示激活的布洛卡区在3/4例低级别胶质瘤（LGG）位于左额叶的右半球。1例高级别胶质瘤（HGG）仅左半球Broca区激活（LI=1）。无论肿瘤的大小和组织学类型如何，都可以在两个半球的Wernicke区激活。所有位于左颞叶的肿瘤均为HGG。我们在4/5的病例中仅在右半球Wernicke区获得激活。在4/5例病例中，Broca区存在激活-2例在左半球，1例在右半球，1例在双侧。结论：与语言区有密切地形关系的肿瘤性病变的存在诱导了语言区的功能重组。功能磁共振成像是一个有用的方法来确定语言区的定位在术前规划。位于Wernicke区附近的HGG肿瘤导致其功能转移到健康半球和/或受影响半球的活动减少。
Summary Background: The aim of this study was to determine the reorganization of the language areas in patients with tumors located near speech centers using functional magnetic resonance imaging (fMRI). Material/Methods: fMRI was performed prior to the surgical treatment of 11 right-handed patients with tumors located close to the Broca’s or Wernicke’s areas of the left hemisphere. The analysis included a record of the activity in four regions of interest (ROIs): Broca’s and Wernicke’s areas, and their anatomic homologues in the right hemisphere. For each patient a regional lateralization index was calculated separately for Broca’s area versus its right-hemisphere homolog and Wernicke’s area versus its right-hemisphere homolog. The results were correlated with the histopathological type of the tumor and its size. Results: Our fMRI examinations showed activation of the Broca’s area in the right hemisphere in 3/4 cases of low grade gliomas (LGG) localized in the left frontal lobe. In one case of the high grade glioma (HGG) only the left hemisphere Broca’s area was activated (LI=1). Activation in Wernicke’s area in both hemispheres was obtained irrespective of the size and histological type of the tumor. All tumors localized in the left temporal lobe were HGG. We obtained activation only in the right hemisphere Wernicke’s area in 4/5 of the cases. In 4/5 of the cases activation in Broca’s area was present- in 2 cases in the left hemisphere, in 1 case in the right hemisphere and in 1 case bilateral. Conclusions: The presence of a neoplastic lesion in close topographic relationship to language areas induces their functional reorganization. fMRI is an useful method for determination of language areas localization in pre-operative planning. HGG tumors localized near Wernicke’s area lead to transfer its function to the healthy hemisphere and/or to decreased activity in the affected hemisphere.
语言在皮层中的位置：功能性磁共振成像和皮层电刺激之间的比较。
DOI：
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发表时间：
1997
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
FitzGerald,DB;Cosgrove,GR;Ronner,S;Jiang,H;Buchbinder,BR;Belliveau,JW;Rosen,BR;Benson,RR
通讯作者：
Benson,RR
影响因子：
4.1
作者：
OJEMANN, G;OJEMANN, J;BERGER, M
通讯作者：
BERGER, M