Do haematopoietic stem cells age?
Do haematopoietic stem cells age?
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DOI：
10.1038/s41577-019-0236-2
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发表时间：
2020-03
期刊：
影响因子：
--
通讯作者：
Rodewald HR
中科院分区：
文献类型：
--
作者：
Dorshkind K;Höfer T;Montecino-Rodriguez E;Pioli PD;Rodewald HR
在造血干细胞（HSC）中积累的遗传缺陷被认为是造血中与年龄相关的变化的原因，包括淋巴细胞生成的下降和向髓系的倾斜。这种以HSC为中心的观点主要是基于研究表明，来自老年小鼠的HSC在移植到受辐射的年轻受体小鼠后表现出这些谱系偏好。在这篇观点文章中，我们认为，对这种方法的依赖导致了关于衰老对造血干细胞影响的不准确结论;相反，我们认为环境的变化有助于造血系统衰老。我们建议，一个完整的了解如何影响造血衰老取决于分析血细胞生产在不受干扰的小鼠。我们描述了如何使用原位命运映射可以实现这一点。这种方法表明，除了任何HSC缺陷之外，下游祖细胞的变化可以解释衰老期间发生的淋巴细胞生成减少和持续的骨髓生成。
Genetic defects that accumulate in haematopoietic stem cells (HSCs) are thought to be responsible for age-related changes in haematopoiesis that include a decline in lymphopoiesis and skewing towards the myeloid lineage. This HSC-centric view is based largely on studies showing that HSCs from aged mice exhibit these lineage biases following transplantation into irradiated young recipient mice. In this Opinion article, we make the case that the reliance on this approach has led to inaccurate conclusions regarding the effects of ageing on blood-forming stem cells; we suggest instead that changes in the environment contribute to haematopoietic system ageing. We propose that a complete understanding of how ageing affects haematopoiesis depends on the analysis of blood cell production in unperturbed mice. We describe how this can be achieved using in situ fate mapping. This approach indicates that changes in downstream progenitors, in addition to any HSC defects, may explain the reduced lymphopoiesis and sustained myelopoiesis that occur during ageing.
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影响因子：
16.6
作者：
Grover A;Sanjuan-Pla A;Thongjuea S;Carrelha J;Giustacchini A;Gambardella A;Macaulay I;Mancini E;Luis TC;Mead A;Jacobsen SE;Nerlov C
通讯作者：
Nerlov C
影响因子：
23.9
作者：
Florian, Maria Carolina;Doerr, Karin;Niebel, Anja;Daria, Deidre;Schrezenmeier, Hubert;Rojewski, Markus;Filippi, Marie-Dominique;Hasenberg, Anja;Gunzer, Matthias;Scharffetter-Kochanek, Karin;Zheng, Yi;Geiger, Hartmut
通讯作者：
Geiger, Hartmut
影响因子：
64.8
作者：
Busch, Katrin;Klapproth, Kay;Rodewald, Hans-Reimer
通讯作者：
Rodewald, Hans-Reimer
影响因子：
23.9
作者：
Dykstra, Brad;Kent, David;Eaves, Connie
通讯作者：
Eaves, Connie
DOI：
10.1084/jem.20111490
发表时间：
2011-12-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Dykstra B;Olthof S;Schreuder J;Ritsema M;de Haan G
通讯作者：
de Haan G