Die-hard survivors: heterogeneity in apoptotic thresholds may underlie chemoresistance.
Die-hard survivors: heterogeneity in apoptotic thresholds may underlie chemoresistance.
复制标题
DOI：
10.1586/14737140.2015.1016425
复制
发表时间：
2015-03
影响因子：
3.3
通讯作者：
Aneja R
中科院分区：
文献类型：
--
作者：
Ogden A;Rida PC;Reid MD;Kucuk O;Aneja R
The unmatched efficacy of microtubule-targeting agents (MTAs) as chemotherapeutics was once assumed to originate from their impact on mitotic processes; however, this misconception is being eroded by amassing data that MTAs instead target interphase functions in patients’ tumors. What remains murky is how MTAs target malignant cells over non-malignant ones if proliferation rates do not distinguish them. In many instances, malignant cells are actually more ‘primed’ for apoptosis than non-malignant ones. Nevertheless, even if most cells within the tumor are more apoptosis-susceptible than those in healthy tissues, there likely exist small subpopulations of apoptosis-resistant clones that engender incomplete responses to MTAs and relapse. Therefore, intratumor heterogeneity in terms of proximity to the apoptotic threshold must be better understood to facilitate the design of chemotherapeutic regimens, which may benefit from including drugs like BH3 mimetics that help in lowering the apoptotic threshold of tumor cells within these chemoresistant subpopulations.
登录
查看更多内容
影响因子：
11.2
作者：
Orth JD;Kohler RH;Foijer F;Sorger PK;Weissleder R;Mitchison TJ
通讯作者：
Mitchison TJ
影响因子：
9
作者：
通讯作者：
--
DOI：
10.1038/nrc3106
发表时间：
2011-10-13
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
影响因子：
6.2
作者：
DEVITA, VT;LEWIS, BJ;MUGGIA, FM
通讯作者：
MUGGIA, FM
影响因子：
3.3
作者：
Mitchison TJ
通讯作者：
Mitchison TJ