Central role of purinergic receptors with inflammation in neuropathic pain-related macrophage-SGC-neuron triad. Neuropharmacology
Central role of purinergic receptors with inflammation in neuropathic pain-related macrophage-SGC-neuron triad. Neuropharmacology
复制标题
嘌呤能受体在神经性疼痛相关巨噬细胞-SGC-神经元三联体炎症中的核心作用。
DOI：
10.1016/j.neuropharm.2023.109445
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发表时间：
2023
影响因子：
4.7
通讯作者：
Shangdong Liang
中科院分区：
文献类型：
--
作者：
Runan Yang;Junpei Du;Lin Li;Xiumei Xu;Shangdong Liang
三磷酸腺苷(ATP)作为细胞外信号分子作用于P2嘌呤能受体。P2嘌呤能受体包括P2X亲离子受体和P2Y代谢性受体。卫星胶质细胞(SGCs)和巨噬细胞表达P2X和P2Y受体。炎症细胞因子和前伤害性介质由激活的巨噬细胞和SGCs释放，作用于神经元，促进兴奋性和放电。在初级感觉神经节，响应损伤信号，SGCs和巨噬细胞聚集在初级感觉神经元周围，形成巨噬细胞-SGc-神经元三联体。除了影响炎症相关神经性疼痛的病理改变外，通过作用于巨噬细胞和SGCs上的P2X和P2Y受体，炎性细胞因子和前伤害性介质也被释放。巨噬细胞和SGCs共同作用，增强和延长神经病理性疼痛。巨噬细胞-SGC-神经元三联体通过三磷酸腺苷和其他炎症介质相互联系，维持和促进炎症相关神经病理性疼痛的发生和发展。
Adenosine triphosphate (ATP) acts on P2 purinergic receptors as an extracellular signaling molecule. P2 purinergic receptors include P2X ionotropic receptors and P2Y metabotropic receptors. Satellite glial cells (SGCs) and macrophages express P2X and P2Y receptors. Inflammatory cytokines and pro-nociceptive mediators are released by activated macrophages and SGCs, which can act on neurons to promote excitability and firing. In the primary sensory ganglia, in response to signals of injury, SGCs and macrophages accumulate around primary sensory neurons, forming a macrophage-SGC-neuron triad. In addition to affecting the pathological alterations of inflammation–related neuropathic pain, inflammatory cytokines and pro-nociceptive mediators are released by the action of ATP on P2X and P2Y receptors in macrophages and SGCs. Macrophages and SGCs work together to enhance and prolong neuropathic pain. The macrophage-SGC-neuron triad communicates with each other through ATP and other inflammatory mediators and maintains and promotes the initiation and development of inflammation related-neuropathic pain.This article is part of the Special Issue on “Purinergic Signaling: 50 years”.