Effects of aldosterone and spironolactone on the isolated perfused rat heart.
Effects of aldosterone and spironolactone on the isolated perfused rat heart.
复制标题
醛固酮和螺内酯对离体灌注大鼠心脏的影响。
DOI：
10.1159/000139412
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发表时间：
1996
期刊：
影响因子：
3.1
通讯作者：
L. Rochette
中科院分区：
文献类型：
--
作者：
D. Moreau;J. Chardigny;L. Rochette
醛固酮拮抗剂用于治疗高血压。然而，醛固酮及其拮抗剂对心脏的影响还没有得到彻底的研究。在本研究中，我们研究了醛固酮和螺内酯对大鼠工作心脏模型的影响。醛固酮(10(-8)m ol/L)可减少冠脉流量，增加主动脉流量和心输出量。螺内酯(10(-5)mol/L)可抑制上述作用。这些结果表明，醛固酮直接影响心脏功能。螺内酯似乎能够抑制醛固酮对心脏的不良影响。确切的机制尚不清楚，但在我们的实验条件下，醛固酮对心脏功能参数的早期影响表明，一种非基因组反应，包括激活不同于传递基因组类固醇作用的受体。
Aldosterone antagonists are used in the treatment of hypertension. However, the cardiac influences of aldosterone and its antagonists have not been thoroughly investigated. In the present study, we investigated the effects of aldosterone and spironolactone on an isolated rat working heart model. Aldosterone (10(-8) mol/l) decreased the coronary flow and increased aortic flow and cardiac output. Spironolactone (10(-5) mol/l) inhibited these effects. These results suggest that aldosterone directly influences the cardiac function. Spironolactone appears able to inhibit the adverse cardiac effects of aldosterone. The exact mechanisms remain to be elucidated, but the early effects of aldosterone under our experimental conditions on the functional parameters of the heart suggest a nongenomic response including activation of receptors different from those transmitting genomic steroid actions.