Role of Insulin Resistance in MAFLD.
Role of Insulin Resistance in MAFLD.
复制标题
胰岛素抵抗在MAFLD中的作用
DOI：
10.3390/ijms22084156
复制
发表时间：
2021-04-16
影响因子：
5.6
通讯作者：
Kadowaki T
中科院分区：
文献类型：
--
作者：
Sakurai Y;Kubota N;Yamauchi T;Kadowaki T
许多研究报告称，代谢功能障碍与非酒精性脂肪性肝病（NAFLD）发展的复杂机制密切相关，这促使人们考虑将NAFLD重新命名为代谢功能障碍相关脂肪性肝病（MAFLD）。在这种情况下，代谢功能障碍包括肥胖、2型糖尿病、高血压、血脂异常和代谢综合征，其中胰岛素抵抗是常见的潜在病理生理学。能量摄入和消耗之间的不平衡导致各种组织中的胰岛素抵抗和肠道微生物群的改变，导致肝脏中的脂肪积累。遗传学的作用也被揭示在肝脂肪积聚和纤维化中。在肝脏中脂肪积累的过程中，细胞内损伤以及肝脏胰岛素抵抗进一步增强炎症、纤维化和致癌作用。来自其他组织的脂肪生成底物供应增加，Irs1的肝脏分区和其他因素，包括ER应激，在伴有肝脏胰岛素抵抗的MAFLD中肝脏从头脂肪生成增加中起着至关重要的作用。在此，我们提供了一个概述的因素和作用，全身和局部胰岛素抵抗的发展和进展的MAFLD。
Many studies have reported that metabolic dysfunction is closely involved in the complex mechanism underlying the development of non-alcoholic fatty liver disease (NAFLD), which has prompted a movement to consider renaming NAFLD as metabolic dysfunction-associated fatty liver disease (MAFLD). Metabolic dysfunction in this context encompasses obesity, type 2 diabetes mellitus, hypertension, dyslipidemia, and metabolic syndrome, with insulin resistance as the common underlying pathophysiology. Imbalance between energy intake and expenditure results in insulin resistance in various tissues and alteration of the gut microbiota, resulting in fat accumulation in the liver. The role of genetics has also been revealed in hepatic fat accumulation and fibrosis. In the process of fat accumulation in the liver, intracellular damage as well as hepatic insulin resistance further potentiates inflammation, fibrosis, and carcinogenesis. Increased lipogenic substrate supply from other tissues, hepatic zonation of Irs1, and other factors, including ER stress, play crucial roles in increased hepatic de novo lipogenesis in MAFLD with hepatic insulin resistance. Herein, we provide an overview of the factors contributing to and the role of systemic and local insulin resistance in the development and progression of MAFLD.
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DOI：
10.1002/hep.29273
发表时间：
2017-10
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
BasuRay S;Smagris E;Cohen JC;Hobbs HH
通讯作者：
Hobbs HH
影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
7.7
作者：
Boden, G;She, PX;Ruderman, N
通讯作者：
Ruderman, N
影响因子：
6.5
作者：
Brown, J. Mark;Betters, Jenna L.;Yu, Liqing
通讯作者：
Yu, Liqing
影响因子：
5.6
作者：
Chang ML;Yang Z;Yang SS
通讯作者：
Yang SS